prfC protein (Prochlorococcus marinus MIT9312)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

prfC

Bacterial peptide chain release factor 3 (bRF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (545 aa)

Predicted Functional Partners:

rpmA

0.851

rpmG

0.831

rplS

0.818

rpmF

0.818

rplT

0.812

rplL

0.801

rplM

0.798

rplQ

0.786

rplI2

0.783

rpl36

0.783

Your Current Organism:

Prochlorococcus marinus MIT9312

NCBI taxonomy Id: 74546
Other names: P. marinus str. MIT 9312, Prochlorococcus marinus str. MIT 9312, Prochlorococcus sp. MIT 9312, Prochlorococcus sp. MIT9312

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
prfC	rpl36	PMT9312_0663	PMT9312_1815	Bacterial peptide chain release factor 3 (bRF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	50S Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.	0.783
prfC	rplI2	PMT9312_0663	PMT9312_1765	Bacterial peptide chain release factor 3 (bRF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	LSU ribosomal protein L9P; Binds to the 23S rRNA.	0.783
prfC	rplL	PMT9312_0663	PMT9312_0203	Bacterial peptide chain release factor 3 (bRF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	LSU ribosomal protein L12P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family.	0.801
prfC	rplM	PMT9312_0663	PMT9312_1625	Bacterial peptide chain release factor 3 (bRF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.798
prfC	rplQ	PMT9312_0663	PMT9312_1627	Bacterial peptide chain release factor 3 (bRF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	LSU ribosomal protein L17P; Alternative locus ID: P9312_17771.	0.786
prfC	rplS	PMT9312_0663	PMT9312_0475	Bacterial peptide chain release factor 3 (bRF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	LSU ribosomal protein L19P; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.	0.818
prfC	rplT	PMT9312_0663	PMT9312_1754	Bacterial peptide chain release factor 3 (bRF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	LSU ribosomal protein L20P; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.812
prfC	rpmA	PMT9312_0663	PMT9312_1443	Bacterial peptide chain release factor 3 (bRF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	LSU ribosomal protein L27P; Alternative locus ID: P9312_15641; Belongs to the bacterial ribosomal protein bL27 family.	0.851
prfC	rpmF	PMT9312_0663	PMT9312_0947	Bacterial peptide chain release factor 3 (bRF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	LSU ribosomal protein L32P; Alternative locus ID: P9312_10111; Belongs to the bacterial ribosomal protein bL32 family.	0.818
prfC	rpmG	PMT9312_0663	PMT9312_0931	Bacterial peptide chain release factor 3 (bRF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	LSU ribosomal protein L33P; Alternative locus ID: P9312_09891; Belongs to the bacterial ribosomal protein bL33 family.	0.831
rpl36	prfC	PMT9312_1815	PMT9312_0663	50S Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.	Bacterial peptide chain release factor 3 (bRF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	0.783
rpl36	rplI2	PMT9312_1815	PMT9312_1765	50S Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.	LSU ribosomal protein L9P; Binds to the 23S rRNA.	0.936
rpl36	rplL	PMT9312_1815	PMT9312_0203	50S Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.	LSU ribosomal protein L12P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family.	0.986
rpl36	rplM	PMT9312_1815	PMT9312_1625	50S Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.	LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.989
rpl36	rplQ	PMT9312_1815	PMT9312_1627	50S Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.	LSU ribosomal protein L17P; Alternative locus ID: P9312_17771.	0.994
rpl36	rplS	PMT9312_1815	PMT9312_0475	50S Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.	LSU ribosomal protein L19P; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.	0.977
rpl36	rplT	PMT9312_1815	PMT9312_1754	50S Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.	LSU ribosomal protein L20P; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.981
rpl36	rpmA	PMT9312_1815	PMT9312_1443	50S Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.	LSU ribosomal protein L27P; Alternative locus ID: P9312_15641; Belongs to the bacterial ribosomal protein bL27 family.	0.962
rpl36	rpmF	PMT9312_1815	PMT9312_0947	50S Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.	LSU ribosomal protein L32P; Alternative locus ID: P9312_10111; Belongs to the bacterial ribosomal protein bL32 family.	0.986
rpl36	rpmG	PMT9312_1815	PMT9312_0931	50S Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.	LSU ribosomal protein L33P; Alternative locus ID: P9312_09891; Belongs to the bacterial ribosomal protein bL33 family.	0.965

page 1 of 6

Server load: medium (52%) [HD]

Permalink

Network

Neighborhood

Experiments

Co-occurrence

Databases

Co-expression

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About