STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A087ZRF2DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (324 aa)    
Predicted Functional Partners:
A0A088AVV3
BRCT domain-containing protein.
   
 0.970
LOC412308
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 0.902
A0A087ZW86
FHA_2 domain-containing protein.
    
 0.882
A0A088A608
Uncharacterized protein; Belongs to the ATP-dependent DNA ligase family.
  
 0.865
Rrp1
DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.
   
 0.851
A0A088A6L9
Ku domain-containing protein.
    
 0.834
lig3
DNA ligase.
  
 0.801
wgn
TNFR-Cys domain-containing protein.
  
 0.778
LOC408752
DNA ligase.
  
 0.778
LOC726638
Uncharacterized protein.
    
 0.767
Your Current Organism:
Apis mellifera
NCBI taxonomy Id: 7460
Other names: A. mellifera, Apis mellifica, European honey bee, Western honey bee, bee, honey bee, honeybee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.