A0A088A3Q0 protein (Apis mellifera) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

A0A088A3Q0

Uncharacterized protein. (503 aa)

Predicted Functional Partners:

A0A088AHQ9

0.935

Pcl

0.786

LOC410059

0.786

A0A088A7Z4

0.741

A0A088ADD5

0.595

A0A088A1Z9

0.544

Scsalpha

0.541

A0A088ACL8

0.536

A0A088ACL9

0.536

A0A088AHI6

0.536

Your Current Organism:

Apis mellifera

NCBI taxonomy Id: 7460
Other names: A. mellifera, Apis mellifica, European honey bee, Western honey bee, bee, honey bee, honeybee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A088A1Z9	A0A088A3Q0	A0A088A1Z9	A0A088A3Q0	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Uncharacterized protein.	0.544
A0A088A1Z9	A0A088AHQ9	A0A088A1Z9	A0A088AHQ9	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Lyase_1 domain-containing protein.	0.845
A0A088A1Z9	LOC410059	A0A088A1Z9	A0A088AKI2	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Citrate synthase; Belongs to the citrate synthase family.	0.978
A0A088A1Z9	Pcl	A0A088A1Z9	A0A087ZPQ5	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Citrate synthase; Belongs to the citrate synthase family.	0.978
A0A088A1Z9	Scsalpha	A0A088A1Z9	A0A088ADV3	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	0.962
A0A088A3Q0	A0A088A1Z9	A0A088A3Q0	A0A088A1Z9	Uncharacterized protein.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.544
A0A088A3Q0	A0A088A7Z4	A0A088A3Q0	A0A088A7Z4	Uncharacterized protein.	FAD-binding PCMH-type domain-containing protein.	0.741
A0A088A3Q0	A0A088ACL8	A0A088A3Q0	A0A088ACL8	Uncharacterized protein.	CBM20 domain-containing protein.	0.536
A0A088A3Q0	A0A088ACL9	A0A088A3Q0	A0A088ACL9	Uncharacterized protein.	GP-PDE domain-containing protein.	0.536
A0A088A3Q0	A0A088ADD5	A0A088A3Q0	A0A088ADD5	Uncharacterized protein.	Cytochrome b5 heme-binding domain-containing protein.	0.595
A0A088A3Q0	A0A088AHI6	A0A088A3Q0	A0A088AHI6	Uncharacterized protein.	GP-PDE domain-containing protein.	0.536
A0A088A3Q0	A0A088AHQ9	A0A088A3Q0	A0A088AHQ9	Uncharacterized protein.	Lyase_1 domain-containing protein.	0.935
A0A088A3Q0	LOC410059	A0A088A3Q0	A0A088AKI2	Uncharacterized protein.	Citrate synthase; Belongs to the citrate synthase family.	0.786
A0A088A3Q0	Pcl	A0A088A3Q0	A0A087ZPQ5	Uncharacterized protein.	Citrate synthase; Belongs to the citrate synthase family.	0.786
A0A088A3Q0	Scsalpha	A0A088A3Q0	A0A088ADV3	Uncharacterized protein.	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	0.541
A0A088A7Z4	A0A088A3Q0	A0A088A7Z4	A0A088A3Q0	FAD-binding PCMH-type domain-containing protein.	Uncharacterized protein.	0.741
A0A088ACL8	A0A088A3Q0	A0A088ACL8	A0A088A3Q0	CBM20 domain-containing protein.	Uncharacterized protein.	0.536
A0A088ACL8	A0A088ACL9	A0A088ACL8	A0A088ACL9	CBM20 domain-containing protein.	GP-PDE domain-containing protein.	0.919
A0A088ACL9	A0A088A3Q0	A0A088ACL9	A0A088A3Q0	GP-PDE domain-containing protein.	Uncharacterized protein.	0.536
A0A088ACL9	A0A088ACL8	A0A088ACL9	A0A088ACL8	GP-PDE domain-containing protein.	CBM20 domain-containing protein.	0.919

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Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.968

expected number of edges:

13

PPI enrichment p-value:

1.77e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006470

Protein dephosphorylation

8 of 403

2.28

6.06

4.16e-14

GO:0005983

Starch catabolic process

4 of 70

2.74

3.7

1.24e-07

GO:0046838

Phosphorylated carbohydrate dephosphorylation

4 of 85

2.65

3.61

1.60e-07

GO:0007623

Circadian rhythm

3 of 400

1.86

1.33

0.0021

GO:0006796

Phosphate-containing compound metabolic process

10 of 8535

1.05

1.27

1.60e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008138

Protein tyrosine/serine/threonine phosphatase activity

5 of 70

2.83

5.41

6.79e-11

GO:0004721

Phosphoprotein phosphatase activity

8 of 558

2.14

5.38

3.00e-13

GO:2001066

Amylopectin binding

3 of 6

3.68

4.11

3.92e-08

GO:0019203

Carbohydrate phosphatase activity

4 of 86

2.65

3.78

7.54e-08

GO:2001070

Starch binding

3 of 45

2.8

2.91

4.48e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009570

Chloroplast stroma

4 of 1452

1.42

0.99

0.0052

GO:0110165

Cellular anatomical entity

10 of 19699

0.69

0.57

0.00045

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:25640

Energy dependent regulation of mTOR by LKB1-AMPK, and CaM pathway

5 of 83

2.76

4.57

2.60e-09

CL:25743

Mixed, incl. AMP binding, and Laforin-like, dual specificity phosphatase domain

4 of 29

3.12

4.53

5.11e-09

CL:40594

Mixed, incl. Positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response, and bZIP transcription factor RISBZ3/4/5

3 of 13

3.34

3.45

5.66e-07

CL:25745

Mixed, incl. Laforin-like, dual specificity phosphatase domain, and AMP binding

3 of 17

3.23

3.29

1.07e-06

CL:40595

Mixed, incl. Positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response, and bZIP transcription factor RISBZ3/4/5

2 of 8

3.38

1.96

0.00029

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-162582

Signal Transduction

5 of 4506

1.03

0.52

0.0474

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0043036

Starch grain

6 of 23

3.4

8.59

1.95e-16

GOCC:0005952

cAMP-dependent protein kinase complex

3 of 12

3.38

3.59

3.23e-07

GOCC:0009501

Amyloplast

3 of 97

2.47

2.2

7.61e-05

GOCC:0110165

Cellular anatomical entity

8 of 8339

0.96

0.92

8.72e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0904

Protein phosphatase

3 of 187

2.19

1.8

0.00034

KW-0460

Magnesium

3 of 742

1.59

0.95

0.0100

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16561

Glycogen recognition site of AMP-activated protein kinase

6 of 26

3.34

8.26

7.32e-16

PF00782

Dual specificity phosphatase, catalytic domain

6 of 33

3.24

8.08

1.32e-15

PF00069

Protein kinase domain

4 of 474

1.91

1.85

0.00015

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045204

Laforin-like, dual specificity phosphatase domain

6 of 9

3.8

9.37

1.17e-17

IPR032640

AMP-activated protein kinase, glycogen-binding domain

6 of 26

3.34

8.18

1.06e-15

IPR000340

Dual specificity phosphatase, catalytic domain

6 of 53

3.03

7.22

3.50e-14

IPR020422

Dual specificity protein phosphatase domain

6 of 57

3.0

7.17

3.95e-14

IPR000387

Tyrosine-specific protein phosphatases domain

6 of 67

2.93

6.96

7.92e-14

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00332

Serine/threonine phosphatases, family 2C, catalytic domain

3 of 40

2.86

2.81

6.91e-06

SM00100

Cyclic nucleotide-monophosphate binding domain

3 of 91

2.5

2.36

3.74e-05

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