STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ParpPoly [ADP-ribose] polymerase. (991 aa)    
Predicted Functional Partners:
A0A088AIJ7
Uncharacterized protein.
  
 
 0.957
LOC412235
Uncharacterized protein; Belongs to the peptidase C14A family.
    
 0.942
A0A088AKB6
CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family.
    
 0.935
LOC726504
zf-CCHH domain-containing protein.
    
 
 0.933
LOC412308
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 0.904
A0A088A6L9
Ku domain-containing protein.
   
 
 0.865
A0A088AVV3
BRCT domain-containing protein.
    
 
 0.811
Smad4
Mothers against decapentaplegic homolog.
     
 0.800
A0A087ZYH4
Uncharacterized protein.
    
 0.790
LOC552498
Uncharacterized protein.
    
 0.784
Your Current Organism:
Apis mellifera
NCBI taxonomy Id: 7460
Other names: A. mellifera, Apis mellifica, European honey bee, Western honey bee, bee, honey bee, honeybee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.