STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sbcDNuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (417 aa)    
Predicted Functional Partners:
AEE13741.1
SMC domain protein; COGs: COG0419 ATPase involved in DNA repair; InterPro IPR003395; KEGG: mhu:Mhun_2080 exonuclease SbcC; PFAM: RecF/RecN/SMC protein, N-terminal; SPTR: Putative uncharacterized protein; IMG reference gene:2504783453; TIGRFAM: exonuclease SbcC.
 0.999
AEE14520.1
5'-3' exonuclease, resolvase-like domain-containing protein; COGs: COG0258 5'-3' exonuclease (including N-terminal domain of PolI); InterPro IPR020046:IPR020047:IPR002421:IPR008918; KEGG: DNA polymerase I; PFAM: 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: 5'-3' exonuclease, N-terminal; Helix-hairpin-helix motif, class 2; SPTR: DNA polymerase I; IMG reference gene:2504784284; PFAM: 5'-3' exonuclease, C-terminal SAM fold; 5'-3' exonuclease, N-terminal resolvase-like domain.
   
 0.952
recA
Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.889
AEE14324.1
Helicase c2; COGs: COG1199 Rad3-related DNA helicase; InterPro IPR006555; KEGG: nth:Nther_1106 helicase C2; SMART: Helicase, ATP-dependent, c2 type; SPTR: Helicase c2; IMG reference gene:2504784070.
   
 0.881
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.802
lig
DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
   
 0.780
AEE15049.1
3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.724
AEE13743.1
InterPro IPR007301:IPR011636; KEGG: bfs:BF2693 hypothetical protein; PFAM: TQO small subunit DoxD; TQO small subunit DoxA; SPTR: Quinol oxidase subunit; IMG reference gene:2504783455; PFAM: TQO small subunit DoxA; TQO small subunit DoxD.
       0.657
AEE14648.1
UvrD/REP helicase; COGs: COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains); InterPro IPR000212; KEGG: tye:THEYE_A1137 UvrD/REP helicase domain protein, putative; PFAM: DNA helicase, UvrD/REP type; SPTR: UvrD/REP helicase domain protein, putative; IMG reference gene:2504784416; PFAM: UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily.
  
  
 0.649
AEE13740.1
Peptidase U32; COGs: COG0826 Collagenase and related protease; InterPro IPR001539; KEGG: tjr:TherJR_1866 peptidase U32; PFAM: Peptidase U32; SPTR: Peptidase U32; IMG reference gene:2504783452; PFAM: Collagenase; Peptidase family U32.
       0.610
Your Current Organism:
Thermodesulfobium narugense
NCBI taxonomy Id: 747365
Other names: T. narugense DSM 14796, Thermodesulfobium narugense DSM 14796, Thermodesulfobium narugense Na82, Thermodesulfobium narugense str. DSM 14796, Thermodesulfobium narugense strain DSM 14796, sulfate-reducing bacterium Na82
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.