STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEE13999.1SUA5/yciO/yrdC domain protein; COGs: COG0009 Putative translation factor (SUA5); InterPro IPR006070; KEGG: tad:TRIADDRAFT_35031 hypothetical protein; PFAM: Sua5/YciO/YrdC, N-terminal; SPTR: Putative uncharacterized protein; IMG reference gene:2504783730; PFAM: yrdC domain; TIGRFAM: Sua5/YciO/YrdC/YwlC family protein. (203 aa)    
Predicted Functional Partners:
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.805
AEE13998.1
Hypothetical protein; IMG reference gene:2504783729.
       0.773
AEE13997.1
Sodium/hydrogen exchanger; COGs: COG0475 Kef-type K+ transport systems membrane components; InterPro IPR006153; KEGG: hau:Haur_4248 sodium/hydrogen exchanger; PFAM: Cation/H+ exchanger; SPTR: Sodium/hydrogen exchanger; IMG reference gene:2504783728; PFAM: Sodium/hydrogen exchanger family.
       0.718
AEE14001.1
Metal dependent phosphohydrolase; COGs: COG2316 hydrolase (HD superfamily); InterPro IPR006675:IPR006674; KEGG: nth:Nther_2011 metal dependent phosphohydrolase; PFAM: Metal-dependent phosphohydrolase, HD region, subdomain; SPTR: Metal dependent phosphohydrolase; TIGRFAM: HDIG; IMG reference gene:2504783732; PFAM: HD domain; TIGRFAM: uncharacterized domain HDIG.
       0.701
AEE13921.1
Uncharacterized protein family UPF0079, ATPase; COGs: COG0802 ATPase or kinase; InterPro IPR003442; KEGG: fno:Fnod_0408 hypothetical protein; PFAM: Uncharacterised protein family UPF0079, ATPase bacteria; SPTR: Putative uncharacterized protein; TIGRFAM: Uncharacterised protein family UPF0079, ATPase bacteria; IMG reference gene:2504783643; PFAM: Uncharacterised P-loop hydrolase UPF0079; TIGRFAM: ATPase, YjeE family.
 
  
 0.689
AEE13996.1
Hypothetical protein; SPTR: NADH dehydrogenase subunit 2; IMG reference gene:2504783727.
       0.678
tsaD
O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.
  
 
 0.661
AEE13995.1
KEGG: hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504783726; PFAM: Aminotransferase class IV.
       0.608
AEE13994.1
COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterPro IPR015890; KEGG: ddf:DEFDS_1304 para-aminobenzoate synthase component I; PFAM: Chorismate binding, C-terminal; PRIAM: Aminodeoxychorismate synthase; SPTR: Para-aminobenzoate synthase component I; IMG reference gene:2504783725; PFAM: chorismate binding enzyme.
       0.592
AEE14853.1
protein-(glutamine-N5) methyltransferase, release factor-specific; COGs: COG2890 Methylase of polypeptide chain release factors; InterPro IPR004556:IPR019874:IPR013216; KEGG: cow:Calow_0888 protein-(glutamine-n5) methyltransferase, release factor-specific; PFAM: Methyltransferase type 11; SPTR: Protein-(Glutamine-N5) methyltransferase, release factor-specific; TIGRFAM: Protein-(glutamine-N5) methyltransferase, release factor-specific; Modification methylase HemK; IMG reference gene:2504784643; PFAM: Methyltransferase small domain; TIGRFAM: HemK family putative methylases; protein-(glut [...]
  
  
 0.559
Your Current Organism:
Thermodesulfobium narugense
NCBI taxonomy Id: 747365
Other names: T. narugense DSM 14796, Thermodesulfobium narugense DSM 14796, Thermodesulfobium narugense Na82, Thermodesulfobium narugense str. DSM 14796, Thermodesulfobium narugense strain DSM 14796, sulfate-reducing bacterium Na82
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