Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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AEE14436.1UPF0235 protein yggU; HAMAP: Protein of unknown function DUF167; InterPro IPR003746; KEGG: brm:Bmur_1218 protein of unknown function DUF167; PFAM: Protein of unknown function DUF167; SPTR: UPF0235 protein Bmur_1218; IMG reference gene:2504784195; PFAM: Uncharacterised ACR, YggU family COG1872; TIGRFAM: TIGR00251 family protein; Belongs to the UPF0235 family. (86 aa)    
Predicted Functional Partners:
AEE14433.1
Protein of unknown function UPF0001; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
  
  
 0.827
AEE14435.1
DivIVA domain protein; InterPro IPR007793:IPR019933; KEGG: aoe:Clos_1411 DivIVA family protein; PFAM: DivIVA; SPTR: DivIVA family protein; TIGRFAM: DivIVA domain; IMG reference gene:2504784194; PFAM: DivIVA protein; TIGRFAM: DivIVA domain.
  
  
 0.802
proC
Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
     
 0.799
AEE14437.1
Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
       0.791
AEE14431.1
ABC-type transporter, integral membrane subunit; COGs: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems permease components; InterPro IPR000515; KEGG: ddf:DEFDS_0133 peptide/nickel ABC transporter permease; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Peptide/nickel ABC transporter, permease; IMG reference gene:2504784190; PFAM: Binding-protein-dependent transport system inner membrane component.
       0.773
uvrB
UvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...]
       0.773
AEE14438.1
L-fuculose-phosphate aldolase; COGs: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerase and aldolase; InterPro IPR001303; KEGG: tsi:TSIB_0907 L-fuculose phosphate aldolase; PFAM: Class II aldolase/adducin, N-terminal; PRIAM: L-fuculose-phosphate aldolase; SPTR: Fuculose-1-phosphate aldolase; IMG reference gene:2504784197; PFAM: Class II Aldolase and Adducin N-terminal domain; TIGRFAM: L-ribulose-5-phosphate 4-epimerase.
       0.773
mtnA
Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
       0.714
AEE14430.1
COGs: COG0050 GTPase - translation elongation factors; InterProIPR000795:IPR004161:IPR004160:IPR004541:IPR 005225; KEGG: dth:DICTH_0835 elongation factor Tu; PFAM: Protein synthesis factor, GTP-binding; Translation elongation factor EFTu/EF1A, domain 2; Translation elongation factor EFTu/EF1A, C-terminal; SPTR: Elongation factor Tu 1; TIGRFAM: Translation elongation factor EFTu/EF1A, bacterial/organelle; Small GTP-binding protein; IMG reference gene:2504784189; PFAM: Elongation factor Tu C-terminal domain; Elongation factor Tu domain 2; Elongation factor Tu GTP binding domain; TIGRFAM: [...]
       0.634
ileS
Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
       0.578
Your Current Organism:
Thermodesulfobium narugense
NCBI taxonomy Id: 747365
Other names: T. narugense DSM 14796, Thermodesulfobium narugense DSM 14796, Thermodesulfobium narugense Na82, Thermodesulfobium narugense str. DSM 14796, Thermodesulfobium narugense strain DSM 14796, sulfate-reducing bacterium Na82
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