STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEE14447.1CRISPR-associated protein Cas6; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). (252 aa)    
Predicted Functional Partners:
cas2
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
   
 0.956
AEE14452.1
CRISPR-associated protein Cas4; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family.
 
   
 0.945
AEE14448.1
InterPro IPR013389:IPR013420; KEGG: CRISPR-associated protein; PFAM: CRISPR-associated protein TM1802; SPTR: CRISPR-associated protein, TM1802 family; TIGRFAM: CRISPR-associated protein Csh1, C-terminal; CRISPR-associated protein TM1802; IMG reference gene:2504784208; PFAM: CRISPR-associated protein TM1802 (cas_TM1802); TIGRFAM: CRISPR-associated protein, TM1802 family; CRISPR-associated protein Cas8b/Csh1, subtype I-B/HMARI.
 
     0.929
AEE14449.1
CRISPR-associated protein, Csh2 family; COGs: COG3649 Uncharacterized protein predicted to be involved in DNA repair; InterPro IPR006482:IPR013419; KEGG: dtu:Dtur_0623 CRISPR-associated protein, Csh2 family; PFAM: CRISPR-associated protein TM1801; SPTR: CRISPR-associated protein, Csh2 family; TIGRFAM: CRISPR-associated protein Csh2; CRISPR-associated protein TM1801; IMG reference gene:2504784209; PFAM: Family of unknown function (DUF694); TIGRFAM: CRISPR-associated protein, CT1132 family; CRISPR-associated protein Cas7/Csh2, subtype I-B/HMARI.
 
   
 0.927
cas1
CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
   
 0.918
AEE14451.1
CRISPR-associated HD domain protein; COGs: COG1203 helicase; InterPro IPR001650:IPR014001:IPR006483:IPR006474; KEGG: tit:Thit_2284 CRISPR-associated helicase Cas3; PFAM: DNA/RNA helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: CRISPR-associated helicase Cas3; TIGRFAM: CRISPR-associated HD domain; Helicase Cas3, CRISPR-associated, core; IMG reference gene:2504784211; PFAM: Helicase conserved C-terminal domain; HD domain; Type III restriction enzyme, res subunit; TIGRFAM: CRISPR-associated helicase Cas3; CRISPR-associated endonuclease Cas3-HD.
 
   
 0.913
AEE14450.1
CRISPR-associated protein Cas5, Hmari subtype; InterPro IPR007552:IPR013421:IPR013422; KEGG: tit:Thit_2285 CRISPR-associated protein Cas5, Hmari subtype; SPTR: CRISPR-associated protein Cas5, Hmari subtype; TIGRFAM: CRISPR-associated protein Cas5, HALMA; CRISPR-associated protein Cas5; IMG reference gene:2504784210; PFAM: CRISPR-associated protein (Cas_Cas5); TIGRFAM: CRISPR-associated protein Cas5, subtype I-B/HMARI; CRISPR-associated protein Cas5, N-terminal domain.
 
   
 0.909
cas1-2
CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
   
 0.452
Your Current Organism:
Thermodesulfobium narugense
NCBI taxonomy Id: 747365
Other names: T. narugense DSM 14796, Thermodesulfobium narugense DSM 14796, Thermodesulfobium narugense Na82, Thermodesulfobium narugense str. DSM 14796, Thermodesulfobium narugense strain DSM 14796, sulfate-reducing bacterium Na82
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