STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
AEE14600.1Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (297 aa)    
Predicted Functional Partners:
AEE15087.1
uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR006366:IPR000878:IPR003754; KEGG: slp:Slip_1426 uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole methylase; Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; PRIAM: Uroporphyrinogen-III C-methyltransferase., Uroporphyrinogen-III synthase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504784886; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD; TIGRFAM: uroporphyrin [...]
 0.999
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.998
AEE14834.1
Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: ccb:Clocel_2205 porphobilinogen synthase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; PRIAM: Porphobilinogen synthase; SPTR: Porphobilinogen synthase; IMG reference gene:2504784623; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.998
AEE14603.1
COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: tmt:Tmath_0434 siroheme synthase; SPTR: Siroheme synthase; TIGRFAM: Sirohaem synthase, N-terminal; IMG reference gene:2504784371; TIGRFAM: siroheme synthase, N-terminal domain.
  
 0.989
hemL
COGs: COG0001 Glutamate-1-semialdehyde aminotransferase; HAMAP: Glutamate-1-semialdehyde 2,1-aminomutase; InterPro IPR004639:IPR005814; KEGG: tmt:Tmath_0437 glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III; PRIAM: Glutamate-1-semialdehyde 2,1-aminomutase; SPTR: Glutamate-1-semialdehyde 2,1-aminomutase; TIGRFAM: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; IMG reference gene:2504784829; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase.
  
 0.976
AEE14596.1
Tyrosine recombinase xerC; COGs: COG4974 Site-specific recombinase XerD; HAMAP: Tyrosine recombinase xerC; InterPro IPR004107:IPR002104; KEGG: dth:DICTH_1414 recombinase; PFAM: Integrase, catalytic core, phage; Integrase, N-terminal SAM-like, phage; SPTR: Integrase family protein; IMG reference gene:2504784364; PFAM: Phage integrase, N-terminal SAM-like domain; Phage integrase family; Belongs to the 'phage' integrase family.
       0.773
trmFO
Methylenetetrahydrofolate--tRNA-(uracil-5-)- methyltransferase trmFO; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily.
       0.773
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.773
AEE14599.1
Hypothetical protein; IMG reference gene:2504784367.
       0.773
AEE14601.1
InterPro IPR002541; KEGG: cni:Calni_1983 cytochrome c assembly protein; PFAM: Cytochrome c assembly protein; SPTR: Cytochrome c assembly protein; IMG reference gene:2504784369; PFAM: Cytochrome C assembly protein.
       0.757
Your Current Organism:
Thermodesulfobium narugense
NCBI taxonomy Id: 747365
Other names: T. narugense DSM 14796, Thermodesulfobium narugense DSM 14796, Thermodesulfobium narugense Na82, Thermodesulfobium narugense str. DSM 14796, Thermodesulfobium narugense strain DSM 14796, sulfate-reducing bacterium Na82
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