STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEE14813.1HAD-superfamily hydrolase, subfamily IA, variant 3; COGs: COG1011 hydrolase (HAD superfamily); InterPro IPR006402:IPR005834; KEGG: tye:THEYE_A1877 HAD-superfamily hydrolase; PFAM: Haloacid dehalogenase-like hydrolase; SPTR: HAD-superfamily hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; IMG reference gene:2504784602; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. (216 aa)    
Predicted Functional Partners:
AEE14858.1
CinA domain protein; COGs: COG1058 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; InterPro IPR008136:IPR001453; KEGG: tme:Tmel_0783 competence/damage-inducible protein CinA; PFAM: Molybdopterin binding; CinA, C-terminal; SPTR: CinA-like protein; TIGRFAM: CinA, C-terminal; IMG reference gene:2504784648; PFAM: Probable molybdopterin binding domain; Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA C-terminal domain; molybdenum cofactor synthesis domain.
    
  0.940
nadD
Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
 
  
 0.923
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
    
  0.922
AEE14909.1
IMP dehydrogenase family protein; InterPro IPR005992:IPR001093; KEGG: ava:Ava_2653 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; SPTR: IMP dehydrogenase related 2; TIGRFAM: IMP dehydrogenase related 2; IMG reference gene:2504784701; PFAM: IMP dehydrogenase / GMP reductase domain; TIGRFAM: IMP dehydrogenase family protein.
  
 0.920
AEE14437.1
Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
  
 
 0.914
AEE14224.1
dCMP deaminase; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR002125; KEGG: cth:Cthe_2599 CMP/dCMP deaminase, zinc-binding; PFAM: CMP/dCMP deaminase, zinc-binding; PRIAM: dCMP deaminase; SPTR: CMP/dCMP deaminase, zinc-binding protein; IMG reference gene:2504783967; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region.
  
 
  0.911
AEE15137.1
COGs: COG1488 Nicotinic acid phosphoribosyltransferase; InterPro IPR002638; KEGG: tba:TERMP_01329 nicotinate phosphoribosyltransferase; PFAM: Quinolinate phosphoribosyl transferase; PRIAM: Nicotinate phosphoribosyltransferase; SPTR: Quinolinate phosphoribosyl transferase, C-terminal domain protein; IMG reference gene:2504784938; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: putative nicotinate phosphoribosyltransferase.
   
 
 0.910
surE
Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.908
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
   
  0.906
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR011607:IPR013982:IPR002695; KEGG: cow:Calow_1224 phosphoribosylaminoimidazolecarboxamide formyltransferase/imp cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme, formylation region; MGS-like; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region; SPTR: Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM [...]
  
 
 0.905
Your Current Organism:
Thermodesulfobium narugense
NCBI taxonomy Id: 747365
Other names: T. narugense DSM 14796, Thermodesulfobium narugense DSM 14796, Thermodesulfobium narugense Na82, Thermodesulfobium narugense str. DSM 14796, Thermodesulfobium narugense strain DSM 14796, sulfate-reducing bacterium Na82
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