STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemLCOGs: COG0001 Glutamate-1-semialdehyde aminotransferase; HAMAP: Glutamate-1-semialdehyde 2,1-aminomutase; InterPro IPR004639:IPR005814; KEGG: tmt:Tmath_0437 glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III; PRIAM: Glutamate-1-semialdehyde 2,1-aminomutase; SPTR: Glutamate-1-semialdehyde 2,1-aminomutase; TIGRFAM: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; IMG reference gene:2504784829; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase. (427 aa)    
Predicted Functional Partners:
AEE14834.1
Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: ccb:Clocel_2205 porphobilinogen synthase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; PRIAM: Porphobilinogen synthase; SPTR: Porphobilinogen synthase; IMG reference gene:2504784623; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.995
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.994
AEE14600.1
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.976
AEE14603.1
COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: tmt:Tmath_0434 siroheme synthase; SPTR: Siroheme synthase; TIGRFAM: Sirohaem synthase, N-terminal; IMG reference gene:2504784371; TIGRFAM: siroheme synthase, N-terminal domain.
   
 0.918
AEE15087.1
uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR006366:IPR000878:IPR003754; KEGG: slp:Slip_1426 uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole methylase; Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; PRIAM: Uroporphyrinogen-III C-methyltransferase., Uroporphyrinogen-III synthase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504784886; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD; TIGRFAM: uroporphyrin [...]
 
  
 0.905
AEE15032.1
COGs: COG1522 Transcriptional regulators; InterPro IPR019888; KEGG: drm:Dred_2157 AsnC family transcriptional regulator; SMART: Transcription regulator, AsnC-type; SPTR: Putative transcriptional regulator, AsnC family; IMG reference gene:2504784828.
     
 0.810
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.648
AEE15031.1
Hypothetical protein; IMG reference gene:2504784827.
       0.616
AEE14630.1
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.584
AEE15046.1
3-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
 
 
  
 0.568
Your Current Organism:
Thermodesulfobium narugense
NCBI taxonomy Id: 747365
Other names: T. narugense DSM 14796, Thermodesulfobium narugense DSM 14796, Thermodesulfobium narugense Na82, Thermodesulfobium narugense str. DSM 14796, Thermodesulfobium narugense strain DSM 14796, sulfate-reducing bacterium Na82
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