STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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thyXThymidylate synthase thyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (216 aa)    
Predicted Functional Partners:
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
    
 0.936
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 0.927
AEE14515.1
Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
    
 0.927
AEE14633.1
Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
     
 0.918
folD
Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.916
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
   
 
 0.912
AEE14224.1
dCMP deaminase; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR002125; KEGG: cth:Cthe_2599 CMP/dCMP deaminase, zinc-binding; PFAM: CMP/dCMP deaminase, zinc-binding; PRIAM: dCMP deaminase; SPTR: CMP/dCMP deaminase, zinc-binding protein; IMG reference gene:2504783967; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region.
    
  0.910
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR011607:IPR013982:IPR002695; KEGG: cow:Calow_1224 phosphoribosylaminoimidazolecarboxamide formyltransferase/imp cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme, formylation region; MGS-like; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region; SPTR: Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM [...]
     
 0.908
AEE14003.1
COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: pmx:PERMA_0068 5,10-methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; PRIAM: Methylenetetrahydrofolate reductase (NAD(P)H); SPTR: 5,10-methylenetetrahydrofolate reductase; IMG reference gene:2504783734; PFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form; Belongs to the methylenetetrahydrofolate reductase family.
     
 0.907
AEE14773.1
COGs: COG0404 Glycine cleavage system T protein (aminomethyltransferase); InterPro IPR006223:IPR006222:IPR013977; KEGG: gur:Gura_0339 glycine cleavage system T protein; PFAM: Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel; PRIAM: Aminomethyltransferase; SPTR: Glycine cleavage system T protein; TIGRFAM: Glycine cleavage system T protein; IMG reference gene:2504784559; PFAM: Aminomethyltransferase folate-binding domain; Glycine cleavage T-protein C-terminal barrel domain; TIGRFAM: glycine cleavage system T protein.
     
 0.905
Your Current Organism:
Thermodesulfobium narugense
NCBI taxonomy Id: 747365
Other names: T. narugense DSM 14796, Thermodesulfobium narugense DSM 14796, Thermodesulfobium narugense Na82, Thermodesulfobium narugense str. DSM 14796, Thermodesulfobium narugense strain DSM 14796, sulfate-reducing bacterium Na82
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