STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEE15152.1Protein of unknown function DUF1212; COGs: COG2966 conserved hypothetical protein; InterPro IPR010619; KEGG: mxa:MXAN_1583 hypothetical protein; PFAM: Protein of unknown function DUF1212; SPTR: Putative membrane protein; IMG reference gene:2504784953; PFAM: Protein of unknown function (DUF1212). (416 aa)    
Predicted Functional Partners:
AEE15151.1
Hypothetical protein; IMG reference gene:2504784952.
       0.561
AEE14201.1
COGs: COG0631 Serine/threonine protein phosphatase; InterPro IPR001932:IPR014045; KEGG: msv:Mesil_2865 protein serine/threonine phosphatase; PFAM: Protein phosphatase 2C, N-terminal; SMART: Protein phosphatase 2C-related; SPTR: Protein serine/threonine phosphatase; IMG reference gene:2504783943; PFAM: Protein phosphatase 2C.
 
     0.531
rpmA
COGs: COG0211 Ribosomal protein L27; HAMAP: Ribosomal protein L27; InterPro IPR001684; KEGG: tde:TDE1749 50S ribosomal protein L27; PFAM: Ribosomal protein L27; SPTR: 50S ribosomal protein L27; TIGRFAM: Ribosomal protein L27; IMG reference gene:2504784772; PFAM: Ribosomal L27 protein; TIGRFAM: ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family.
 
     0.496
AEE13740.1
Peptidase U32; COGs: COG0826 Collagenase and related protease; InterPro IPR001539; KEGG: tjr:TherJR_1866 peptidase U32; PFAM: Peptidase U32; SPTR: Peptidase U32; IMG reference gene:2504783452; PFAM: Collagenase; Peptidase family U32.
 
     0.489
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.482
rpoZ
DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
    0.476
AEE15120.1
Diguanylate cyclase/phosphodiesterase with CBS domains; COGs: COG2200 FOG: EAL domain; InterPro IPR000160:IPR001633:IPR000644; KEGG: ckr:CKR_1966 hypothetical protein; PFAM: Diguanylate phosphodiesterase, predicted; Cystathionine beta-synthase, core; Diguanylate cyclase, predicted; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; SPTR: Putative uncharacterized protein; TIGRFAM: Diguanylate cyclase, predicted; manually curated; IMG reference gene:2504784920; PFAM: EAL domain; CBS domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain.
  
    0.473
AEE13967.1
Diguanylate cyclase with PAS/PAC sensor; COGs: COG2199 FOG: GGDEF domain; InterPro IPR000014:IPR000160; KEGG: dau:Daud_0417 diguanylate cyclase with PAS/PAC sensor; PFAM: Diguanylate cyclase, predicted; SMART: Diguanylate cyclase, predicted; SPTR: Diguanylate cyclase and metal dependent phosphohydrolase; TIGRFAM: Diguanylate cyclase, predicted; PAS; IMG reference gene:2504783697; PFAM: GGDEF domain; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain.
  
    0.471
obg
GTPase obg; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
  
    0.471
AEE14061.1
Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterProIPR000014:IPR000160:IPR001633:IPR013767:IPR 003018:IPR013655; KEGG: nis:NIS_0136 hypothetical protein; PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; PAS fold-3; GAF; PAS fold; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; PAS; SPTR: Putative uncharacterized protein; TIGRFAM: Diguanylate cyclase, predicted; PAS; IMG reference gene:2504783796; PFA [...]
  
    0.460
Your Current Organism:
Thermodesulfobium narugense
NCBI taxonomy Id: 747365
Other names: T. narugense DSM 14796, Thermodesulfobium narugense DSM 14796, Thermodesulfobium narugense Na82, Thermodesulfobium narugense str. DSM 14796, Thermodesulfobium narugense strain DSM 14796, sulfate-reducing bacterium Na82
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