STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (188 aa)    
Predicted Functional Partners:
AEE15431.1
Adenosylmethionine--8-amino-7-oxononanoate transaminase; COGs: COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; InterPro IPR005814; KEGG: ddf:DEFDS_1299 adenosylmethionine--8-amino-7-oxononanoate transaminase; PFAM: Aminotransferase class-III; PRIAM: Adenosylmethionine--8-amino-7-oxononanoate transaminase; SPTR: Adenosylmethionine--8-amino-7-oxononanoate transaminase; IMG reference gene:2504785242; PFAM: Aminotransferase class-III; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase [...]
 
 
 0.999
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
 
 
 0.996
AEE15125.1
Radical SAM domain protein; COGs: COG0502 Biotin synthase; InterPro IPR006638:IPR007197; KEGG: drm:Dred_2151 biotin synthase; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein; IMG reference gene:2504784925; PFAM: Radical SAM superfamily; TIGRFAM: iron-only hydrogenase maturation rSAM protein HydE.
 
 
 0.987
AEE15438.1
8-amino-7-oxononanoate synthase; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839; KEGG: ddf:DEFDS_1301 8-amino-7-oxononanoate synthase; PFAM: Aminotransferase, class I/II; PRIAM: 8-amino-7-oxononanoate synthase; SPTR: 8-amino-7-oxononanoate synthase; IMG reference gene:2504785249; PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase.
 
  
 0.963
AEE15433.1
COGs: COG3467 flavin-nucleotide-binding protein; KEGG: abu:Abu_0989 putative antibiotic resistance protein; SPTR: Putative antibiotic resistance protein; IMG reference gene:2504785244; PFAM: Pyridoxamine 5'-phosphate oxidase.
       0.752
AEE15434.1
Methyltransferase type 12; InterPro IPR013217; KEGG: ddf:DEFDS_1303 biotin biosynthesis protein BioC; PFAM: Methyltransferase type 12; SPTR: Biotin biosynthesis protein BioC; IMG reference gene:2504785245; PFAM: Methyltransferase domain.
 
  
 0.681
AEE14630.1
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.585
ribBA
GTP cyclohydrolase-2; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
     
 0.577
AEE15430.1
COGs: COG1757 Na+/H+ antiporter; InterPro IPR018461; KEGG: bse:Bsel_1008 Na+/H+ antiporter NhaC-like protein; PFAM: Na+/H+ antiporter NhaC-like; SPTR: Na+/H+ antiporter; IMG reference gene:2504785241; PFAM: Na+/H+ antiporter family.
       0.561
AEE15143.1
Methyltransferase type 11; InterPro IPR013216; KEGG: dol:Dole_1540 methyltransferase type 11; PFAM: Methyltransferase type 11; SPTR: Methyltransferase type 11; IMG reference gene:2504784944; PFAM: Methyltransferase domain.
  
  
 0.482
Your Current Organism:
Thermodesulfobium narugense
NCBI taxonomy Id: 747365
Other names: T. narugense DSM 14796, Thermodesulfobium narugense DSM 14796, Thermodesulfobium narugense Na82, Thermodesulfobium narugense str. DSM 14796, Thermodesulfobium narugense strain DSM 14796, sulfate-reducing bacterium Na82
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