| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MALL_0103 | MALL_0575 | MALL_0103 | MALL_0575 | Putative 2-deoxy-D-gluconate 3-dehydrogenase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF00106. | Sugar-phosphate isomerase, RpiB/LacA/LacB family; Identified by match to protein family HMM PF02502; match to protein family HMM TIGR00689. | 0.839 |
| MALL_0103 | folA | MALL_0103 | MALL_0417 | Putative 2-deoxy-D-gluconate 3-dehydrogenase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF00106. | Dihydrofolate reductase; Identified by match to protein family HMM PF00186; Belongs to the dihydrofolate reductase family. | 0.583 |
| MALL_0103 | glyA | MALL_0103 | MALL_0820 | Putative 2-deoxy-D-gluconate 3-dehydrogenase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF00106. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.698 |
| MALL_0103 | thyA | MALL_0103 | MALL_0418 | Putative 2-deoxy-D-gluconate 3-dehydrogenase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF00106. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.544 |
| MALL_0477 | folA | MALL_0477 | MALL_0417 | Cytidine and deoxycytidylate deaminase zinc-binding region; Identified by match to protein family HMM PF00383. | Dihydrofolate reductase; Identified by match to protein family HMM PF00186; Belongs to the dihydrofolate reductase family. | 0.880 |
| MALL_0477 | tdk | MALL_0477 | MALL_0724 | Cytidine and deoxycytidylate deaminase zinc-binding region; Identified by match to protein family HMM PF00383. | Thymidine kinase; Identified by match to protein family HMM PF00265. | 0.922 |
| MALL_0477 | thyA | MALL_0477 | MALL_0418 | Cytidine and deoxycytidylate deaminase zinc-binding region; Identified by match to protein family HMM PF00383. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.874 |
| MALL_0477 | tmk | MALL_0477 | MALL_0397 | Cytidine and deoxycytidylate deaminase zinc-binding region; Identified by match to protein family HMM PF00383. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.856 |
| MALL_0575 | MALL_0103 | MALL_0575 | MALL_0103 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; Identified by match to protein family HMM PF02502; match to protein family HMM TIGR00689. | Putative 2-deoxy-D-gluconate 3-dehydrogenase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF00106. | 0.839 |
| MALL_0575 | folA | MALL_0575 | MALL_0417 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; Identified by match to protein family HMM PF02502; match to protein family HMM TIGR00689. | Dihydrofolate reductase; Identified by match to protein family HMM PF00186; Belongs to the dihydrofolate reductase family. | 0.543 |
| MALL_0575 | folD | MALL_0575 | MALL_0743 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; Identified by match to protein family HMM PF02502; match to protein family HMM TIGR00689. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.698 |
| MALL_0575 | glyA | MALL_0575 | MALL_0820 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; Identified by match to protein family HMM PF02502; match to protein family HMM TIGR00689. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.942 |
| MALL_0575 | thyA | MALL_0575 | MALL_0418 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; Identified by match to protein family HMM PF02502; match to protein family HMM TIGR00689. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.535 |
| fmt | folA | MALL_0726 | MALL_0417 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Dihydrofolate reductase; Identified by match to protein family HMM PF00186; Belongs to the dihydrofolate reductase family. | 0.680 |
| fmt | folD | MALL_0726 | MALL_0743 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.831 |
| fmt | glyA | MALL_0726 | MALL_0820 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.645 |
| fmt | pheT | MALL_0726 | MALL_0821 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | phenylalanyl-tRNA synthetase, beta subunit; Identified by match to protein family HMM PF03483; match to protein family HMM TIGR00472. | 0.703 |
| fmt | thyA | MALL_0726 | MALL_0418 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.515 |
| folA | MALL_0103 | MALL_0417 | MALL_0103 | Dihydrofolate reductase; Identified by match to protein family HMM PF00186; Belongs to the dihydrofolate reductase family. | Putative 2-deoxy-D-gluconate 3-dehydrogenase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF00106. | 0.583 |
| folA | MALL_0477 | MALL_0417 | MALL_0477 | Dihydrofolate reductase; Identified by match to protein family HMM PF00186; Belongs to the dihydrofolate reductase family. | Cytidine and deoxycytidylate deaminase zinc-binding region; Identified by match to protein family HMM PF00383. | 0.880 |
