STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A168IBY0DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (849 aa)    
Predicted Functional Partners:
A0A168L924
Uncharacterized protein.
   
 0.998
A0A162RV98
3'-5' exonuclease domain-containing protein.
  
 0.996
A0A168GRY0
RMI1_N domain-containing protein.
    
 0.988
A0A168MYM7
Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
   
 0.941
A0A168MB16
ERCC4 domain-containing protein.
    
 0.934
A0A168J231
ERCC4 domain-containing protein.
    
 0.927
A0A162QG28
HRDC domain-containing protein.
  
 0.879
A0A162QS31
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
  
 0.879
A0A168H512
Uncharacterized protein.
  
 0.879
A0A168PWP0
Helicase ATP-binding domain-containing protein.
  
 0.879
Your Current Organism:
Mucor circinelloides f. lusitanicus
NCBI taxonomy Id: 747725
Other names: M. circinelloides f. lusitanicus CBS 277.49, Mucor circinelloides f. lusitanicus CBS 277.49
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