STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)    
Predicted Functional Partners:
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
NH8B_1009
Succinate dehydrogenase and fumarate reductase iron-sulfur protein; K00240; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
 
 0.995
NH8B_1008
Succinate dehydrogenase, flavoprotein subunit; K00239; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 
 0.993
NH8B_1006
Succinate dehydrogenase, cytochrome b556 subunit; K00241.
  
 
 0.990
NH8B_1013
2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
  
 0.981
NH8B_1007
Succinate dehydrogenase, hydrophobic membrane anchor protein; K00242.
  
 
 0.961
aceF
Branched-chain alpha-keto acid dehydrogenase subunit E2; K00627.
  
 0.952
NH8B_2459
Dihydrolipoamide acetyltransferase; K00627.
  
 0.952
NH8B_3879
Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.952
NH8B_1012
2-oxoglutarate dehydrogenase, E1 subunit; K00164.
 
 
 0.944
Your Current Organism:
Pseudogulbenkiania sp. NH8B
NCBI taxonomy Id: 748280
Other names: P. sp. NH8B
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.