STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobAuroporphyrin-III C-methyltransferase; K02303; Belongs to the precorrin methyltransferase family. (279 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.988
cobA-3
uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
 
 
0.966
NH8B_0096
uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 
 0.947
NH8B_1835
Precorrin-2 C20-methyltransferase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A.
 
 
 0.947
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.927
cobA-2
uroporphyrin-III C-methyltransferase; K02303.
  
  
 
0.911
NH8B_0097
HemX family protein; K02496.
     
 0.903
NH8B_0817
Sulfite reductase (NADPH) hemoprotein, beta subunit; K00381.
 
  
 0.898
NH8B_0844
Porphobilinogen synthase; K01698; Belongs to the ALAD family.
 
  
 0.880
cbiC
precorrin-8X methylmutase CbiC/CobH; K06042.
  
 0.831
Your Current Organism:
Pseudogulbenkiania sp. NH8B
NCBI taxonomy Id: 748280
Other names: P. sp. NH8B
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