Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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iscSCysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (391 aa)    
Predicted Functional Partners:
AGB41729.1
PFAM: NifU-like N terminal domain; TIGRFAM: FeS cluster assembly scaffold protein NifU, Clostridium type.
 
 0.998
thiI
Thiazole biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
 0.964
AGB42217.1
Dinucleotide-utilizing enzyme possibly involved in molybdopterin or thiamin biosynthesis; PFAM: MoeZ/MoeB domain; ThiF family.
   
 0.951
AGB42069.1
Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain.
  
 0.936
AGB41114.1
Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain.
   
 0.911
AGB42067.1
Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain.
   
 0.911
AGB41297.1
Cysteine desulfurase family protein; PFAM: Aminotransferase class-V.
  
  
 
0.910
AGB41731.1
PFAM: Transcriptional regulator; TIGRFAM: Rrf2 family protein.
  
  
 0.906
AGB40447.1
PFAM: Aminotransferase class-V; TIGRFAM: cysteine desulfurase NifS.
  
  
 
0.904
AGB42229.1
NAD(FAD)-dependent dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; DsrE/DsrF-like family; SirA-like protein; Rhodanese-like domain; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Belongs to the sulfur carrier protein TusA family.
   
 
 0.854
Your Current Organism:
Halobacteroides halobius
NCBI taxonomy Id: 748449
Other names: H. halobius DSM 5150, Halobacteroides halobius ATCC 35273, Halobacteroides halobius DSM 5150, Halobacteroides halobius MD-1, Halobacteroides halobius str. DSM 5150, Halobacteroides halobius strain DSM 5150
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