STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADV45360.1Hydrogenase expression/formation protein HypD; COGs: COG0409 Hydrogenase maturation factor; InterPro IPR002780; KEGG: nis:NIS_0976 hydrogenase expression/formation protein HypD; PFAM: hydrogenase formation HypD protein; SPTR: Hydrogenase expression/formation protein HypD; TIGRFAM: hydrogenase expression/formation protein HypD; PFAM: Hydrogenase formation hypA family; TIGRFAM: hydrogenase expression/formation protein HypD; Belongs to the HypD family. (386 aa)    
Predicted Functional Partners:
ADV45361.1
Hydrogenase expression/formation protein HypE; COGs: COG0309 Hydrogenase maturation factor; InterPro IPR011854: IPR000728: IPR010918; KEGG: sun:SUN_1646 hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; SPTR: Hydrogenase expression/formation protein HypE; TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: hydrogenase expression/formation protein HypE.
 
 0.998
ADV45359.1
Hydrogenase assembly chaperone hypC/hupF; COGs: COG0298 Hydrogenase maturation factor; InterPro IPR001109; KEGG: nis:NIS_0975 hydrogenase expression/formation protein HupF/HypC; PFAM: hydrogenase expression/formation protein (HUPF/HYPC); SPTR: Hydrogenase expression/formation protein HupF/HypC; TIGRFAM: hydrogenase assembly chaperone hypC/hupF; PFAM: HupF/HypC family; TIGRFAM: hydrogenase assembly chaperone HypC/HupF.
 
 
 0.997
ADV45358.1
Hydrogenase accessory protein HypB; COGs: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; InterPro IPR004392: IPR007087: IPR003495: IPR012202; KEGG: abu:Abu_1408 hydrogenase expression/formation protein HypB; PFAM: cobalamin synthesis protein P47K; SPTR: Hydrogenase expression/formation protein HypB; TIGRFAM: hydrogenase accessory protein HypB; PFAM: CobW/HypB/UreG, nucleotide-binding domain; TIGRFAM: hydrogenase accessory protein HypB.
 
  
 0.981
hypA
Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
  
 0.958
ADV45352.1
(NiFe) hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
  
 0.889
ADV45345.1
COGs: COG3259 Coenzyme F420-reducing hydrogenase alpha subunit; InterPro IPR001501; KEGG: tdn:Suden_1437 nickel-dependent hydrogenase, large subunit; PFAM: nickel-dependent hydrogenase large subunit; SPTR: Nickel-dependent hydrogenase, large subunit; PFAM: Nickel-dependent hydrogenase.
 
 
 0.837
ADV45362.1
COGs: COG0223 Methionyl-tRNA formyltransferase; InterPro IPR002376: IPR005793: IPR001753: IPR009188; KEGG: nis:NIS_0978 hydrogenase maturation protein HoxX; PFAM: formyl transferase domain protein; Enoyl-CoA hydratase/isomerase; SPTR: Hydrogenase maturation protein HoxX; PFAM: Enoyl-CoA hydratase/isomerase family; Formyl transferase; Formyl transferase, C-terminal domain.
  
    0.812
ADV45348.1
COGs: COG0374 Ni Fe-hydrogenase I large subunit; InterPro IPR018194: IPR001501; KEGG: nis:NIS_0964 Ni-Fe hydrogenase, large subunit; PFAM: nickel-dependent hydrogenase large subunit; SPTR: Hydrogen-uptake [NiFe] hydrogenase large subunit; PFAM: Nickel-dependent hydrogenase; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.680
ADV45356.1
KEGG: nam:NAMH_0735 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.671
ADV45357.1
ABC transporter related protein; COGs: COG1122 ABC-type cobalt transport system ATPase component; InterPro IPR017871: IPR003439: IPR003593; KEGG: nam:NAMH_0736 cobalt import ATP-binding protein CbiO 2; PFAM: ABC transporter related; SMART: AAA ATPase; SPTR: ABC transporter-related protein; PFAM: ABC transporter.
       0.671
Your Current Organism:
Nitratifractor salsuginis
NCBI taxonomy Id: 749222
Other names: N. salsuginis DSM 16511, Nitratifractor salsuginis DSM 16511, Nitratifractor salsuginis E9I37-1, Nitratifractor salsuginis str. DSM 16511, Nitratifractor salsuginis strain DSM 16511
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