STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADV45811.1Histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR005467: IPR001789: IPR004358: IPR003661: IPR 003594; KEGG: nis:NIS_1346 two-component sensor histidine kinase/response regulator; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; SPTR: Two-component sensor histidine kinase/response regulator; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Nitrate and nitrite sensing; [...] (822 aa)    
Predicted Functional Partners:
ADV45678.1
COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterProIPR005467: IPR000014: IPR000700: IPR004358: IPR 001610: IPR003594: IPR013655; KEGG: tdn:Suden_1243 PAS/PAC sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; PAS fold-3 domain protein; SMART: ATP-binding region ATPase domain protein; PAC repeat-containing protein; PAS domain containing protein; SPTR: PAS/PAC sensor signal transduction histidine kinase; TIGRFAM: PAS sensor protein; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase [...]
 
0.980
ADV46868.1
COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR001789: IPR000160; KEGG: dap:Dacet_1843 diguanylate cyclase; PFAM: GGDEF domain containing protein; response regulator receiver; SMART: GGDEF domain containing protein; response regulator receiver; SPTR: Response regulator PleD; TIGRFAM: diguanylate cyclase; PFAM: Response regulator receiver domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain.
 
 0.963
ADV46486.1
Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterProIPR013656: IPR013767: IPR000160: IPR001633: IPR 007565: IPR000014: IPR000700; KEGG: mei:Msip34_1854 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain protein; GGDEF domain containing protein; PAS fold-4 domain protein; PAS fold domain protein; protein of unknown function DUF556; SMART: EAL domain protein; GGDEF domain containing protein; PAS domain containing protein; SPTR: Diguanylate cyclas [...]
 
 0.901
ADV45687.1
COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR001789; KEGG: sun:SUN_1905 hypothetical protein; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Putative uncharacterized protein; PFAM: Response regulator receiver domain.
 
 
0.894
ADV46869.1
Histidine kinase; COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterProIPR001638: IPR003594: IPR004358: IPR005467: IPR 003661; KEGG: wsu:WS0850 sensory transduction histidine kinase; PFAM: extracellular solute-binding protein family 3; histidine kinase A domain protein; ATP-binding region ATPase domain protein; SMART: extracellular solute-binding protein family 3; ATP-binding region ATPase domain protein; SPTR: SENSORY TRANSDUCTION HISTIDINE KINASE; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Bacterial extracellular [...]
 
 0.891
ADV45362.1
COGs: COG0223 Methionyl-tRNA formyltransferase; InterPro IPR002376: IPR005793: IPR001753: IPR009188; KEGG: nis:NIS_0978 hydrogenase maturation protein HoxX; PFAM: formyl transferase domain protein; Enoyl-CoA hydratase/isomerase; SPTR: Hydrogenase maturation protein HoxX; PFAM: Enoyl-CoA hydratase/isomerase family; Formyl transferase; Formyl transferase, C-terminal domain.
  
 
 0.867
ADV45537.1
Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterProIPR000014: IPR000160: IPR013655: IPR001633: IPR 001610: IPR000700; KEGG: rxy:Rxyl_0492 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain protein; GGDEF domain containing protein; PAS fold-3 domain protein; SMART: EAL domain protein; GGDEF domain containing protein; PAC repeat-containing protein; SPTR: Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S); TIGRFAM: diguanylate cyclase; [...]
 
 0.862
ADV46319.1
Two component transcriptional regulator, winged helix family; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789: IPR001867; KEGG: sun:SUN_1144 two-component response regulator; PFAM: response regulator receiver; transcriptional regulator domain-containing protein; SMART: response regulator receiver; SPTR: Two-component response regulator; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal.
 
 
 0.839
ADV45688.1
Integral membrane sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR005467: IPR001789: IPR004358: IPR003661: IPR 003594; KEGG: sun:SUN_1904 two-component sensor histidine kinase/response regulator; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; SPTR: Two-component sensor histidine kinase/response regulator; PFAM: Response regulator receiver domain; Histidine kinase-, [...]
 
 
 
0.824
ADV45930.1
Diguanylate cyclase/phosphodiesterase; COGs: COG2200 FOG: EAL domain; InterPro IPR000160: IPR001633; KEGG: sun:SUN_1965 hypothetical protein; PFAM: EAL domain protein; GGDEF domain containing protein; SMART: EAL domain protein; GGDEF domain containing protein; SPTR: Putative uncharacterized protein; TIGRFAM: diguanylate cyclase; PFAM: EAL domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain.
  
 0.823
Your Current Organism:
Nitratifractor salsuginis
NCBI taxonomy Id: 749222
Other names: N. salsuginis DSM 16511, Nitratifractor salsuginis DSM 16511, Nitratifractor salsuginis E9I37-1, Nitratifractor salsuginis str. DSM 16511, Nitratifractor salsuginis strain DSM 16511
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