STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADV47253.1Aminotransferase class I and II; COGs: COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; InterPro IPR004839; KEGG: sun:SUN_0398 aminotransferase; PFAM: aminotransferase class I and II; SPTR: Aminotransferase; PFAM: Aminotransferase class I and II. (397 aa)    
Predicted Functional Partners:
ADV45697.1
COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR006235: IPR000277; KEGG: sun:SUN_1791 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cysteine synthase; SPTR: O-acetylhomoserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase.
   
 0.933
ADV45426.1
COGs: COG0031 Cysteine synthase; InterPro IPR005856: IPR005859: IPR001216: IPR001926; KEGG: mta:Moth_1971 cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Cysteine synthase; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family.
    
 0.929
ADV45752.1
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
     
 0.929
ADV46738.1
Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839: IPR001176: IPR004838; KEGG: sun:SUN_1362 aspartate aminotransferase; PFAM: aminotransferase class I and II; SPTR: Aspartate aminotransferase; manually curated; PFAM: Aminotransferase class I and II.
  
  
0.913
ADV46515.1
COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: sun:SUN_0641 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
    
 0.908
metE
Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
    
  0.900
luxS
Quorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
     
  0.900
ADV47252.1
D-alanyl-D-alaninecarboxypeptidase/ D-alanyl-D-alanine-endopeptidase; COGs: COG2027 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4); InterPro IPR000667; KEGG: sun:SUN_0399 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase; PFAM: peptidase S13 D-Ala-D-Ala carboxypeptidase C; PRIAM: Serine-type D-Ala-D-Ala carboxypeptidase; SPTR: D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase; TIGRFAM: D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase; PFAM: D-Ala-D-Ala carboxypeptidase 3 (S13) family; TIGRFAM: D-alanyl-D-alan [...]
 
     0.822
ADV45676.1
Xaa-His dipeptidase; COGs: COG2195 Di- and tripeptidase; InterPro IPR001160: IPR002933; KEGG: sun:SUN_1808 aminoacyl-histidine dipeptidase; PFAM: peptidase M20; PRIAM: Xaa-His dipeptidase; SPTR: Aminoacyl-histidine dipeptidase; PFAM: Peptidase family M20/M25/M40; TIGRFAM: aminoacyl-histidine dipeptidase.
    
  0.813
ADV45744.1
L-threonine ammonia-lyase; COGs: COG1171 Threonine dehydratase; InterPro IPR005789: IPR000634: IPR001926; KEGG: sun:SUN_1827 threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Threonine dehydratase; TIGRFAM: threonine dehydratase; PFAM: C-terminal regulatory domain of Threonine dehydratase; Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine dehydratase, medium form.
    
  0.813
Your Current Organism:
Nitratifractor salsuginis
NCBI taxonomy Id: 749222
Other names: N. salsuginis DSM 16511, Nitratifractor salsuginis DSM 16511, Nitratifractor salsuginis E9I37-1, Nitratifractor salsuginis str. DSM 16511, Nitratifractor salsuginis strain DSM 16511
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