STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADV47358.1COGs: COG0232 dGTP triphosphohydrolase; InterPro IPR006261: IPR003607: IPR006674; KEGG: sun:SUN_0043 deoxyguanosinetriphosphate triphosphohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; SPTR: Deoxyguanosinetriphosphate triphosphohydrolase; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase; PFAM: HD domain; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase, putative; Belongs to the dGTPase family. Type 2 subfamily. (368 aa)    
Predicted Functional Partners:
surE
5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
  0.911
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 
  0.901
ADV45800.1
5'-nucleotidase; InterPro IPR010394; KEGG: sun:SUN_1006 5'-nucleotidase; PFAM: 5-nucleotidase; PRIAM: 5'-nucleotidase; SPTR: 5'-nucleotidase; PFAM: 5'-nucleotidase.
     
  0.900
ADV46621.1
Ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; InterPro IPR013345; KEGG: nis:NIS_0814 hypothetical protein; PRIAM: Ribonucleoside-triphosphate reductase; SPTR: Probable adenosylcobalamin-dependent ribonucleoside-triphosphate reductase; TIGRFAM: ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; PFAM: Ribonucleotide reductase, barrel domain; TIGRFAM: ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent.
    
  0.900
ADV47157.1
COGs: COG0469 Pyruvate kinase; InterPro IPR001697: IPR015793: IPR015794; KEGG: sun:SUN_0436 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PRIAM: Pyruvate kinase; SPTR: Pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family.
     
  0.900
thyX
Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
       0.606
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
    
 0.526
ADV47357.1
GTP-binding protein TypA; COGs: COG1217 membrane GTPase involved in stress response; InterProIPR005225: IPR006298: IPR000795: IPR004161: IPR 000640; KEGG: sun:SUN_2356 GTP-binding protein TypA; PFAM: protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; elongation factor G domain-containing protein; SPTR: GTP-binding protein TypA; TIGRFAM: GTP-binding protein TypA; small GTP-binding protein; PFAM: Elongation factor Tu domain 2; Elongation factor G C-terminus; Elongation factor Tu GTP binding domain; TIGRFAM: GTP-binding protein TypA/BipA; small GTP-binding protei [...]
       0.442
ADV47360.1
ErfK/YbiS/YcfS/YnhG family protein; COGs: COG2989 conserved hypothetical protein; InterPro IPR002477: IPR005490; KEGG: sun:SUN_2290 hypothetical protein; PFAM: ErfK/YbiS/YcfS/YnhG family protein; Peptidoglycan-binding domain 1 protein; SPTR: Putative uncharacterized protein; PFAM: L,D-transpeptidase catalytic domain.
       0.431
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.401
Your Current Organism:
Nitratifractor salsuginis
NCBI taxonomy Id: 749222
Other names: N. salsuginis DSM 16511, Nitratifractor salsuginis DSM 16511, Nitratifractor salsuginis E9I37-1, Nitratifractor salsuginis str. DSM 16511, Nitratifractor salsuginis strain DSM 16511
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