node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SBI_00883 | SBI_04273 | SBI_00883 | SBI_04273 | COG1171 Threonine dehydratase. | COG1171 Threonine dehydratase. | 0.918 |
SBI_00883 | ilvB1 | SBI_00883 | SBI_00397 | COG1171 Threonine dehydratase. | Putative acetolactate synthase, large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | 0.931 |
SBI_00883 | ilvB2 | SBI_00883 | SBI_02714 | COG1171 Threonine dehydratase. | Putative TPP-requiring protein; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | 0.941 |
SBI_00883 | ilvB3 | SBI_00883 | SBI_03557 | COG1171 Threonine dehydratase. | Acetolactate synthase 1 catalytic subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 0.941 |
SBI_00883 | ilvC | SBI_00883 | SBI_03555 | COG1171 Threonine dehydratase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.750 |
SBI_00883 | ilvH | SBI_00883 | SBI_03556 | COG1171 Threonine dehydratase. | COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.965 |
SBI_00883 | leuB | SBI_00883 | SBI_03531 | COG1171 Threonine dehydratase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.924 |
SBI_00883 | leuC | SBI_00883 | SBI_03511 | COG1171 Threonine dehydratase. | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.457 |
SBI_00883 | leuD | SBI_00883 | SBI_03510 | COG1171 Threonine dehydratase. | Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.579 |
SBI_04273 | SBI_00883 | SBI_04273 | SBI_00883 | COG1171 Threonine dehydratase. | COG1171 Threonine dehydratase. | 0.918 |
SBI_04273 | ilvB1 | SBI_04273 | SBI_00397 | COG1171 Threonine dehydratase. | Putative acetolactate synthase, large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | 0.940 |
SBI_04273 | ilvB2 | SBI_04273 | SBI_02714 | COG1171 Threonine dehydratase. | Putative TPP-requiring protein; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | 0.931 |
SBI_04273 | ilvB3 | SBI_04273 | SBI_03557 | COG1171 Threonine dehydratase. | Acetolactate synthase 1 catalytic subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 0.941 |
SBI_04273 | ilvC | SBI_04273 | SBI_03555 | COG1171 Threonine dehydratase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.750 |
SBI_04273 | ilvH | SBI_04273 | SBI_03556 | COG1171 Threonine dehydratase. | COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.965 |
SBI_04273 | leuB | SBI_04273 | SBI_03531 | COG1171 Threonine dehydratase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.924 |
SBI_04273 | leuC | SBI_04273 | SBI_03511 | COG1171 Threonine dehydratase. | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.431 |
SBI_04273 | leuD | SBI_04273 | SBI_03510 | COG1171 Threonine dehydratase. | Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.564 |
ilvB1 | SBI_00883 | SBI_00397 | SBI_00883 | Putative acetolactate synthase, large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | COG1171 Threonine dehydratase. | 0.931 |
ilvB1 | SBI_04273 | SBI_00397 | SBI_04273 | Putative acetolactate synthase, large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | COG1171 Threonine dehydratase. | 0.940 |