Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
FAD_0100Indole-3-glycerol-phosphate synthase. (237 aa)    
Predicted Functional Partners:
FAD_0101
Anthranilate synthase component II.
 
  
 0.999
FAD_0102
Anthranilate synthase component I.
 
 
 0.999
trpF
N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family.
 
 
 0.999
FAD_0104
Anthranilate phosphoribosyltransferase.
 
  
 0.999
FAD_0105
Tryptophan synthase alpha chain.
 
 
 0.999
trpB
Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
 
 0.993
FAD_0099
3-deoxy-7-phosphoheptulonate synthase.
  
  
 0.857
FAD_0107
Triosephosphate isomerase; Belongs to the triosephosphate isomerase family.
  
  
 0.725
hisG
ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
  
 0.629
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.628
Your Current Organism:
Ferroplasma acidiphilum
NCBI taxonomy Id: 74969
Other names: DSM 12658, F. acidiphilum, Ferromonas metallovorans, Ferroplasma acidiphilum Golyshina et al. 2000, JCM 10970
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