Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
FAD_0198uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (239 aa)    
Predicted Functional Partners:
FAD_0197
Porphobilinogen deaminase.
  
 0.999
FAD_0338
Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit.
     
 0.993
FAD_0339
uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
  
 
 0.971
FAD_1345
Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
  
 
 0.969
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.950
hemL
Glutamate-1-semialdehyde aminotransferase.
  
  
 0.944
FAD_0614
Siroheme synthase, putative.
  
 
 0.855
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
  
 0.817
recJ
single-stranded-DNA-specific exonuclease RecJ.
       0.593
srp19
Signal recognition particle subunit SRP19.
       0.593
Your Current Organism:
Ferroplasma acidiphilum
NCBI taxonomy Id: 74969
Other names: DSM 12658, F. acidiphilum, Ferromonas metallovorans, Ferroplasma acidiphilum Golyshina et al. 2000, JCM 10970
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