| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FAD_0197 | FAD_0198 | FAD_0197 | FAD_0198 | Porphobilinogen deaminase. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.999 |
| FAD_0197 | FAD_0338 | FAD_0197 | FAD_0338 | Porphobilinogen deaminase. | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit. | 0.992 |
| FAD_0197 | FAD_0339 | FAD_0197 | FAD_0339 | Porphobilinogen deaminase. | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.990 |
| FAD_0197 | FAD_0614 | FAD_0197 | FAD_0614 | Porphobilinogen deaminase. | Siroheme synthase, putative. | 0.763 |
| FAD_0197 | FAD_1345 | FAD_0197 | FAD_1345 | Porphobilinogen deaminase. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.999 |
| FAD_0197 | cbiA | FAD_0197 | FAD_0799 | Porphobilinogen deaminase. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.445 |
| FAD_0197 | cobS | FAD_0197 | FAD_1479 | Porphobilinogen deaminase. | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.515 |
| FAD_0197 | hemA | FAD_0197 | FAD_0680 | Porphobilinogen deaminase. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.993 |
| FAD_0197 | hemL | FAD_0197 | FAD_0196 | Porphobilinogen deaminase. | Glutamate-1-semialdehyde aminotransferase. | 0.992 |
| FAD_0198 | FAD_0197 | FAD_0198 | FAD_0197 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase. | 0.999 |
| FAD_0198 | FAD_0338 | FAD_0198 | FAD_0338 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit. | 0.993 |
| FAD_0198 | FAD_0339 | FAD_0198 | FAD_0339 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.971 |
| FAD_0198 | FAD_0614 | FAD_0198 | FAD_0614 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Siroheme synthase, putative. | 0.855 |
| FAD_0198 | FAD_1345 | FAD_0198 | FAD_1345 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.969 |
| FAD_0198 | cbiA | FAD_0198 | FAD_0799 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.455 |
| FAD_0198 | cobS | FAD_0198 | FAD_1479 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.437 |
| FAD_0198 | hemA | FAD_0198 | FAD_0680 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.817 |
| FAD_0198 | hemL | FAD_0198 | FAD_0196 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Glutamate-1-semialdehyde aminotransferase. | 0.944 |
| FAD_0338 | FAD_0197 | FAD_0338 | FAD_0197 | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit. | Porphobilinogen deaminase. | 0.992 |
| FAD_0338 | FAD_0198 | FAD_0338 | FAD_0198 | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.993 |