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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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co-expression
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[Homology]
Score
FAD_11893-hydroxy-3-methylglutaryl-coenzyme A reductase. (401 aa)    
Predicted Functional Partners:
FAD_0050
Hypothetical protein; Belongs to the thiolase-like superfamily. UPF0219 family.
 
 
 0.998
FAD_0787
Diphosphomevalonate decarboxylase.
  
 
 0.932
FAD_0513
acetyl-CoA acetyltransferase.
 
  
 0.912
FAD_1242
acetyl-CoA acetyltransferase.
 
  
 0.912
FAD_1246
Acetyl-CoA acetyltransferase; Frameshift and an internal stop codon in nucleotidyltransferase gene.
 
  
 0.911
fni
Isopentenyl pyrophosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
   
 0.874
fen1
Flap endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Act [...]
      
 0.797
FAD_1190
Tetratricopeptide repeat-containing protein.
       0.795
FAD_0051
acetyl-CoA acetyltransferase.
  
  
 0.790
rad50
Chromosome segregation protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily.
      
 0.788
Your Current Organism:
Ferroplasma acidiphilum
NCBI taxonomy Id: 74969
Other names: DSM 12658, F. acidiphilum, Ferromonas metallovorans, Ferroplasma acidiphilum Golyshina et al. 2000, JCM 10970
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