| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FAD_0810 | FAD_1222 | FAD_0810 | FAD_1222 | Glycerol kinase. | (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase. | 0.503 |
| FAD_0810 | FAD_1427 | FAD_0810 | FAD_1427 | Glycerol kinase. | Geranylgeranylglyceryl phosphate synthase-like protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | 0.463 |
| FAD_0810 | egsA | FAD_0810 | FAD_0289 | Glycerol kinase. | NAD(P)-dependent glycerol-1-phosphate dehydrogenase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Belongs to the glycerol-1-phosphate dehydrogenase family. | 0.452 |
| FAD_1079 | FAD_1222 | FAD_1079 | FAD_1222 | Digeranylgeranylglycerophospholipid reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains; Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily. | (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase. | 0.972 |
| FAD_1079 | FAD_1427 | FAD_1079 | FAD_1427 | Digeranylgeranylglycerophospholipid reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains; Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily. | Geranylgeranylglyceryl phosphate synthase-like protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | 0.403 |
| FAD_1079 | carS | FAD_1079 | FAD_0022 | Digeranylgeranylglycerophospholipid reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains; Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily. | Hypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | 0.945 |
| FAD_1079 | fixC | FAD_1079 | FAD_1660 | Digeranylgeranylglycerophospholipid reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains; Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily. | Oxidoreductase with FAD/NAD(P)-binding domain. | 0.430 |
| FAD_1083 | FAD_1222 | FAD_1083 | FAD_1222 | succinyl-CoA synthetase. | (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase. | 0.658 |
| FAD_1222 | FAD_0810 | FAD_1222 | FAD_0810 | (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase. | Glycerol kinase. | 0.503 |
| FAD_1222 | FAD_1079 | FAD_1222 | FAD_1079 | (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase. | Digeranylgeranylglycerophospholipid reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains; Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily. | 0.972 |
| FAD_1222 | FAD_1083 | FAD_1222 | FAD_1083 | (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase. | succinyl-CoA synthetase. | 0.658 |
| FAD_1222 | FAD_1223 | FAD_1222 | FAD_1223 | (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase. | Hypothetical protein. | 0.539 |
| FAD_1222 | FAD_1427 | FAD_1222 | FAD_1427 | (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase. | Geranylgeranylglyceryl phosphate synthase-like protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | 0.995 |
| FAD_1222 | FAD_1736 | FAD_1222 | FAD_1736 | (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase. | Geranylgeranyl reductase. | 0.832 |
| FAD_1222 | carS | FAD_1222 | FAD_0022 | (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase. | Hypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | 0.969 |
| FAD_1222 | egsA | FAD_1222 | FAD_0289 | (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase. | NAD(P)-dependent glycerol-1-phosphate dehydrogenase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Belongs to the glycerol-1-phosphate dehydrogenase family. | 0.677 |
| FAD_1222 | fixC | FAD_1222 | FAD_1660 | (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase. | Oxidoreductase with FAD/NAD(P)-binding domain. | 0.555 |
| FAD_1222 | nac | FAD_1222 | FAD_1845 | (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase. | Nascent polypeptide-associated complex protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family. | 0.694 |
| FAD_1223 | FAD_1222 | FAD_1223 | FAD_1222 | Hypothetical protein. | (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase. | 0.539 |
| FAD_1427 | FAD_0810 | FAD_1427 | FAD_0810 | Geranylgeranylglyceryl phosphate synthase-like protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | Glycerol kinase. | 0.463 |