STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tint_2016Site-specific DNA-methyltransferase (adenine-specific); KEGG: gur:Gura_0593 DNA methylase N-4/N-6 domain-containing protein; PFAM: DNA methylase N-4/N-6 domain protein. (1138 aa)    
Predicted Functional Partners:
Tint_2015
PFAM: type III restriction protein res subunit; KEGG: aeh:Mlg_1542 DEAD/DEAH box helicase domain-containing protein.
 
   
 0.964
Tint_1530
PFAM: type III restriction protein res subunit; KEGG: gme:Gmet_0675 type III restriction enzyme, res subunit.
 
   
 0.721
Tint_2365
KEGG: reu:Reut_A0211 hypothetical protein.
  
  
 0.603
Tint_2017
PFAM: filamentation induced by cAMP protein Fic; KEGG: bur:Bcep18194_B2094 filamentation induced by cAMP protein Fic.
     
 0.543
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
   
    0.489
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
   
    0.489
Tint_2018
TIGRFAM: DNA topoisomerase III; PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; KEGG: afe:Lferr_0283 DNA topoisomerase III; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein.
  
  
 0.480
Tint_1029
Sigma 54 interacting domain protein; KEGG: bmj:BMULJ_00613 DnaA regulatory inactivator Hda; PFAM: Chromosomal replication initiator DnaA; SMART: AAA ATPase; Belongs to the DnaA family.
     
 0.429
infB
Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
 
   
 0.429
Tint_1549
PFAM: Putative helicase A859L; KEGG: pau:PA14_15600 hypothetical protein.
     
 0.420
Your Current Organism:
Thiomonas intermedia
NCBI taxonomy Id: 75379
Other names: T. intermedia K12, Thiobacillus intermedius K12, Thiomonas intermedia K12, Thiomonas intermedia str. K12, Thiomonas intermedia strain K12
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