Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tint_2018TIGRFAM: DNA topoisomerase III; PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; KEGG: afe:Lferr_0283 DNA topoisomerase III; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein. (723 aa)    
Predicted Functional Partners:
Tint_2181
TIGRFAM: ATP-dependent DNA helicase RecQ; ATP-dependent DNA helicase, RecQ family; PFAM: RQC domain; DEAD/DEAH box helicase domain protein; helicase domain protein; HRDC domain protein; KEGG: bgl:bglu_1g02520 ATP-dependent DNA helicase RecQ; SMART: DEAD-like helicase; helicase domain protein; HRDC domain protein.
 
 0.938
Tint_2017
PFAM: filamentation induced by cAMP protein Fic; KEGG: bur:Bcep18194_B2094 filamentation induced by cAMP protein Fic.
       0.739
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
   
 0.721
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
  
 
 0.690
Tint_2117
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily.
  
 
 0.681
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.671
Tint_1039
PFAM: UvrD/REP helicase; KEGG: mpt:Mpe_A1142 ATP-dependent DNA helicase UvrD.
  
 0.648
rep
UvrD/REP helicase; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.
  
 0.648
rpoC
DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.581
Tint_2019
PFAM: Lytic transglycosylase catalytic; KEGG: pna:Pnap_2494 lytic transglycosylase, catalytic.
  
  
 0.545
Your Current Organism:
Thiomonas intermedia
NCBI taxonomy Id: 75379
Other names: T. intermedia K12, Thiobacillus intermedius K12, Thiomonas intermedia K12, Thiomonas intermedia str. K12, Thiomonas intermedia strain K12
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