| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBL55652.1 | caiC | PFREUD_01340 | PFREUD_02440 | Diacylglycerol kinase, catalytic region. | Crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle. | 0.635 |
| CBL55652.1 | cypA | PFREUD_01340 | PFREUD_23710 | Diacylglycerol kinase, catalytic region. | Cytochrome P450 (Heme-thiolate monooxygenase). | 0.853 |
| CBL55652.1 | rplF | PFREUD_01340 | PFREUD_05860 | Diacylglycerol kinase, catalytic region. | 50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. | 0.774 |
| acpP | caiC | PFREUD_09420 | PFREUD_02440 | Acyl carrier protein (ACP); Carrier of the growing fatty acid chain in fatty acid biosynthesis. | Crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle. | 0.636 |
| acpP | cypA | PFREUD_09420 | PFREUD_23710 | Acyl carrier protein (ACP); Carrier of the growing fatty acid chain in fatty acid biosynthesis. | Cytochrome P450 (Heme-thiolate monooxygenase). | 0.813 |
| acpP | fixA | PFREUD_09420 | PFREUD_02480 | Acyl carrier protein (ACP); Carrier of the growing fatty acid chain in fatty acid biosynthesis. | Electron transfer flavoprotein (FixA protein); Required for anaerobic carnitine reduction. May bring reductant to caiA. | 0.443 |
| caiA | caiB | PFREUD_02420 | PFREUD_02430 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | 0.928 |
| caiA | caiC | PFREUD_02420 | PFREUD_02440 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | Crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle. | 0.889 |
| caiA | fixA | PFREUD_02420 | PFREUD_02480 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | Electron transfer flavoprotein (FixA protein); Required for anaerobic carnitine reduction. May bring reductant to caiA. | 0.978 |
| caiA | fixC | PFREUD_02420 | PFREUD_02500 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | Electron transfer flavoprotein-quinone oxidoreductase (FixC protein). | 0.781 |
| caiA | maoC | PFREUD_02420 | PFREUD_02450 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | MaoC acyl dehydratase. | 0.917 |
| caiA | yaaU | PFREUD_02420 | PFREUD_02460 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | Metabolite transport protein YaaU; Belongs to the major facilitator superfamily. Sugar transporter. | 0.589 |
| caiB | caiA | PFREUD_02430 | PFREUD_02420 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | 0.928 |
| caiB | caiC | PFREUD_02430 | PFREUD_02440 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | Crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle. | 0.928 |
| caiB | fixA | PFREUD_02430 | PFREUD_02480 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | Electron transfer flavoprotein (FixA protein); Required for anaerobic carnitine reduction. May bring reductant to caiA. | 0.828 |
| caiB | fixC | PFREUD_02430 | PFREUD_02500 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | Electron transfer flavoprotein-quinone oxidoreductase (FixC protein). | 0.764 |
| caiB | maoC | PFREUD_02430 | PFREUD_02450 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | MaoC acyl dehydratase. | 0.940 |
| caiB | yaaU | PFREUD_02430 | PFREUD_02460 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | Metabolite transport protein YaaU; Belongs to the major facilitator superfamily. Sugar transporter. | 0.781 |
| caiC | CBL55652.1 | PFREUD_02440 | PFREUD_01340 | Crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle. | Diacylglycerol kinase, catalytic region. | 0.635 |
| caiC | acpP | PFREUD_02440 | PFREUD_09420 | Crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle. | Acyl carrier protein (ACP); Carrier of the growing fatty acid chain in fatty acid biosynthesis. | 0.636 |