| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| caiA | caiB | PFREUD_02420 | PFREUD_02430 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | 0.928 |
| caiA | caiC | PFREUD_02420 | PFREUD_02440 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | Crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle. | 0.889 |
| caiA | fixA | PFREUD_02420 | PFREUD_02480 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | Electron transfer flavoprotein (FixA protein); Required for anaerobic carnitine reduction. May bring reductant to caiA. | 0.978 |
| caiA | fixB | PFREUD_02420 | PFREUD_02490 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | Electron transfer flavoprotein, carnitine metabolism (FixB protein); Required for anaerobic carnitine reduction. May bring reductant to caiA. | 0.997 |
| caiA | katA | PFREUD_02420 | PFREUD_23800 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | Catalase; Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide, 2 H2O2 = O2 + 2 H2O, Heme group, cofactor NADPH, Homotetramer, Cytoplasm, catalase family. | 0.583 |
| caiA | maoC | PFREUD_02420 | PFREUD_02450 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | MaoC acyl dehydratase. | 0.917 |
| caiA | yaaU | PFREUD_02420 | PFREUD_02460 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | Metabolite transport protein YaaU; Belongs to the major facilitator superfamily. Sugar transporter. | 0.589 |
| caiB | caiA | PFREUD_02430 | PFREUD_02420 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | 0.928 |
| caiB | caiC | PFREUD_02430 | PFREUD_02440 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | Crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle. | 0.928 |
| caiB | fixA | PFREUD_02430 | PFREUD_02480 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | Electron transfer flavoprotein (FixA protein); Required for anaerobic carnitine reduction. May bring reductant to caiA. | 0.828 |
| caiB | fixB | PFREUD_02430 | PFREUD_02490 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | Electron transfer flavoprotein, carnitine metabolism (FixB protein); Required for anaerobic carnitine reduction. May bring reductant to caiA. | 0.788 |
| caiB | maoC | PFREUD_02430 | PFREUD_02450 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | MaoC acyl dehydratase. | 0.940 |
| caiB | yaaU | PFREUD_02430 | PFREUD_02460 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | Metabolite transport protein YaaU; Belongs to the major facilitator superfamily. Sugar transporter. | 0.781 |
| caiC | caiA | PFREUD_02440 | PFREUD_02420 | Crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle. | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | 0.889 |
| caiC | caiB | PFREUD_02440 | PFREUD_02430 | Crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle. | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | 0.928 |
| caiC | fixA | PFREUD_02440 | PFREUD_02480 | Crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle. | Electron transfer flavoprotein (FixA protein); Required for anaerobic carnitine reduction. May bring reductant to caiA. | 0.667 |
| caiC | fixB | PFREUD_02440 | PFREUD_02490 | Crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle. | Electron transfer flavoprotein, carnitine metabolism (FixB protein); Required for anaerobic carnitine reduction. May bring reductant to caiA. | 0.565 |
| caiC | maoC | PFREUD_02440 | PFREUD_02450 | Crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle. | MaoC acyl dehydratase. | 0.928 |
| caiC | yaaU | PFREUD_02440 | PFREUD_02460 | Crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle. | Metabolite transport protein YaaU; Belongs to the major facilitator superfamily. Sugar transporter. | 0.715 |
| fabG | fabH | PFREUD_14870 | PFREUD_09430 | 3-oxoacyl-[acyl-carrier protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 3-oxoacyl-(Acyl-carrier-protein) synthase III; Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacyl-[acyl-carrier-protein] + CoA + CO2; Belongs to the thiolase-like superfamily. FabH family. | 0.993 |