| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| caiA | caiB | PFREUD_02420 | PFREUD_02430 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | 0.928 |
| caiA | caiC | PFREUD_02420 | PFREUD_02440 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | Crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle. | 0.889 |
| caiA | fixA | PFREUD_02420 | PFREUD_02480 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | Electron transfer flavoprotein (FixA protein); Required for anaerobic carnitine reduction. May bring reductant to caiA. | 0.978 |
| caiA | fixB | PFREUD_02420 | PFREUD_02490 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | Electron transfer flavoprotein, carnitine metabolism (FixB protein); Required for anaerobic carnitine reduction. May bring reductant to caiA. | 0.997 |
| caiA | fixC | PFREUD_02420 | PFREUD_02500 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | Electron transfer flavoprotein-quinone oxidoreductase (FixC protein). | 0.781 |
| caiA | fixX | PFREUD_02420 | PFREUD_02510 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | Ferredoxin-like protein fixX. | 0.843 |
| caiA | maoC | PFREUD_02420 | PFREUD_02450 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | MaoC acyl dehydratase. | 0.917 |
| caiA | yaaU | PFREUD_02420 | PFREUD_02460 | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | Metabolite transport protein YaaU; Belongs to the major facilitator superfamily. Sugar transporter. | 0.589 |
| caiB | caiA | PFREUD_02430 | PFREUD_02420 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | 0.928 |
| caiB | caiC | PFREUD_02430 | PFREUD_02440 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | Crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle. | 0.928 |
| caiB | dmsA | PFREUD_02430 | PFREUD_20610 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | Anaerobic dimethyl sulfoxide reductase chain A; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.504 |
| caiB | fixA | PFREUD_02430 | PFREUD_02480 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | Electron transfer flavoprotein (FixA protein); Required for anaerobic carnitine reduction. May bring reductant to caiA. | 0.828 |
| caiB | fixB | PFREUD_02430 | PFREUD_02490 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | Electron transfer flavoprotein, carnitine metabolism (FixB protein); Required for anaerobic carnitine reduction. May bring reductant to caiA. | 0.788 |
| caiB | fixC | PFREUD_02430 | PFREUD_02500 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | Electron transfer flavoprotein-quinone oxidoreductase (FixC protein). | 0.764 |
| caiB | fixX | PFREUD_02430 | PFREUD_02510 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | Ferredoxin-like protein fixX. | 0.740 |
| caiB | maoC | PFREUD_02430 | PFREUD_02450 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | MaoC acyl dehydratase. | 0.940 |
| caiB | yaaU | PFREUD_02430 | PFREUD_02460 | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | Metabolite transport protein YaaU; Belongs to the major facilitator superfamily. Sugar transporter. | 0.781 |
| caiC | caiA | PFREUD_02440 | PFREUD_02420 | Crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle. | Crotonobetainyl-CoA dehydrogenase (Crotonobetainyl-CoA reductase); Fatty acid metabolism and xenobiotic degradation. | 0.889 |
| caiC | caiB | PFREUD_02440 | PFREUD_02430 | Crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle. | Crotonobetainyl-CoA:carnitine CoA-transferase; Engemann et al. Cai locus and corresponding enzymes of Proteus sp; Belongs to the CoA-transferase III family. | 0.928 |
| caiC | fixA | PFREUD_02440 | PFREUD_02480 | Crotonobetaine/carnitine-CoA ligase; Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle. | Electron transfer flavoprotein (FixA protein); Required for anaerobic carnitine reduction. May bring reductant to caiA. | 0.667 |