STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppdk6 Protein of unknown function, without similarity to other proteins; Belongs to the PEP-utilizing enzyme family. (885 aa)    
Predicted Functional Partners:
nifJ1
Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin, which reduces nitrogenase, Pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin.
    
 0.985
nifJ2
Pyruvate:ferredoxin (Flavodoxin) oxidoreductase.
    
 0.983
PPA0888
NAD-dependent malic enzyme (NAD-ME) (Malate dehydrogenase); The protein has been identified by proteomics as a 70 kDa / PI 5.9 protein induced by various stresses including starvation.
   
 
 0.946
pyk1
Pyruvate kinase 1; ATP + Pyruvate <=> ADP + Phosphoenolpyruvate; Belongs to the pyruvate kinase family.
     
 0.945
CBL55744.1
Hypothetical secreted protein.
  
  
 0.942
eno1
Enolase 1; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
    
 0.939
CBL56066.1
Pyruvate flavodoxin/ferredoxin oxidoreductase.
    
 0.937
ldh1
L-Lactate dehydrogenase; (S)-Lactate + NAD+ <=> Pyruvate + NADH + H+; Belongs to the LDH/MDH superfamily.
  
 
 0.936
ldh2
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate.
  
 
 0.936
eno2
Enolase 2; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
    
 0.920
Your Current Organism:
Propionibacterium freudenreichii
NCBI taxonomy Id: 754252
Other names: P. freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii ATCC 9614, Propionibacterium freudenreichii subsp. shermanii CIP 103027, Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii str. CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii strain CIRM-BIA1
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