| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBL55859.1 | CBL55861.1 | PFREUD_03280 | PFREUD_03300 | ABC-type transport systems, periplasmic component. | ABC transporter, permease protein. | 0.999 |
| CBL55859.1 | CBL57663.1 | PFREUD_03280 | PFREUD_21610 | ABC-type transport systems, periplasmic component. | Sulfate-binding protein precursor. | 0.407 |
| CBL55859.1 | metE | PFREUD_03280 | PFREUD_10720 | ABC-type transport systems, periplasmic component. | Methionine synthase, vitamin-B12 independent; 5-Methyltetrahydropteroyltri-L-glutamate + L-Homocysteine <=> Tetrahydropteroyltri-L-glutamate + L-Methionine. | 0.405 |
| CBL55859.1 | metF | PFREUD_03280 | PFREUD_15670 | ABC-type transport systems, periplasmic component. | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H; Belongs to the methylenetetrahydrofolate reductase family. | 0.440 |
| CBL55859.1 | metH | PFREUD_03280 | PFREUD_11340 | ABC-type transport systems, periplasmic component. | Methionine synthase (5-methyltetrahydrofolate:L-homocysteine S-methyltransferase); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.450 |
| CBL55859.1 | metK | PFREUD_03280 | PFREUD_11410 | ABC-type transport systems, periplasmic component. | S-adenosylmethionine synthetase (Methionine adenosyltransferase) (AdoMet synthetase) (MAT); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.447 |
| CBL55859.1 | metN | PFREUD_03280 | PFREUD_03290 | ABC-type transport systems, periplasmic component. | Methionine import ATP-binding protein metN; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.999 |
| CBL55861.1 | CBL55859.1 | PFREUD_03300 | PFREUD_03280 | ABC transporter, permease protein. | ABC-type transport systems, periplasmic component. | 0.999 |
| CBL55861.1 | metF | PFREUD_03300 | PFREUD_15670 | ABC transporter, permease protein. | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H; Belongs to the methylenetetrahydrofolate reductase family. | 0.451 |
| CBL55861.1 | metN | PFREUD_03300 | PFREUD_03290 | ABC transporter, permease protein. | Methionine import ATP-binding protein metN; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.999 |
| CBL57663.1 | CBL55859.1 | PFREUD_21610 | PFREUD_03280 | Sulfate-binding protein precursor. | ABC-type transport systems, periplasmic component. | 0.407 |
| metE | CBL55859.1 | PFREUD_10720 | PFREUD_03280 | Methionine synthase, vitamin-B12 independent; 5-Methyltetrahydropteroyltri-L-glutamate + L-Homocysteine <=> Tetrahydropteroyltri-L-glutamate + L-Methionine. | ABC-type transport systems, periplasmic component. | 0.405 |
| metE | metF | PFREUD_10720 | PFREUD_15670 | Methionine synthase, vitamin-B12 independent; 5-Methyltetrahydropteroyltri-L-glutamate + L-Homocysteine <=> Tetrahydropteroyltri-L-glutamate + L-Methionine. | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H; Belongs to the methylenetetrahydrofolate reductase family. | 0.920 |
| metE | metH | PFREUD_10720 | PFREUD_11340 | Methionine synthase, vitamin-B12 independent; 5-Methyltetrahydropteroyltri-L-glutamate + L-Homocysteine <=> Tetrahydropteroyltri-L-glutamate + L-Methionine. | Methionine synthase (5-methyltetrahydrofolate:L-homocysteine S-methyltransferase); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.838 |
| metE | metK | PFREUD_10720 | PFREUD_11410 | Methionine synthase, vitamin-B12 independent; 5-Methyltetrahydropteroyltri-L-glutamate + L-Homocysteine <=> Tetrahydropteroyltri-L-glutamate + L-Methionine. | S-adenosylmethionine synthetase (Methionine adenosyltransferase) (AdoMet synthetase) (MAT); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.886 |
| metF | CBL55859.1 | PFREUD_15670 | PFREUD_03280 | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H; Belongs to the methylenetetrahydrofolate reductase family. | ABC-type transport systems, periplasmic component. | 0.440 |
| metF | CBL55861.1 | PFREUD_15670 | PFREUD_03300 | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H; Belongs to the methylenetetrahydrofolate reductase family. | ABC transporter, permease protein. | 0.451 |
| metF | metE | PFREUD_15670 | PFREUD_10720 | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H; Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase, vitamin-B12 independent; 5-Methyltetrahydropteroyltri-L-glutamate + L-Homocysteine <=> Tetrahydropteroyltri-L-glutamate + L-Methionine. | 0.920 |
| metF | metH | PFREUD_15670 | PFREUD_11340 | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H; Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase (5-methyltetrahydrofolate:L-homocysteine S-methyltransferase); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
| metF | metK | PFREUD_15670 | PFREUD_11410 | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H; Belongs to the methylenetetrahydrofolate reductase family. | S-adenosylmethionine synthetase (Methionine adenosyltransferase) (AdoMet synthetase) (MAT); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.775 |