| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBL55973.1 | add | PFREUD_04390 | PFREUD_04380 | 6 Protein of unknown function, without similarity to other proteins. | Adenosine deaminase (Adenosine aminohydrolase); Adenosine + H2O <=> Inosine + NH3 and Deoxyadenosine + H2O <=> Deoxyinosine + NH3 and Cyclic amidines + H2O <=> Cyclic amide + NH3. | 0.505 |
| CBL55973.1 | sbcC | PFREUD_04390 | PFREUD_04360 | 6 Protein of unknown function, without similarity to other proteins. | ATP-dependent dsDNA exonuclease SbcC; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3prime->5prime double strand exonuclease that can open hairpins. It also has a 5prim single-strand endonuclease activity. | 0.505 |
| CBL55973.1 | sbcD | PFREUD_04390 | PFREUD_04370 | 6 Protein of unknown function, without similarity to other proteins. | SbcD, DNA repair exonuclease; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.505 |
| add | CBL55973.1 | PFREUD_04380 | PFREUD_04390 | Adenosine deaminase (Adenosine aminohydrolase); Adenosine + H2O <=> Inosine + NH3 and Deoxyadenosine + H2O <=> Deoxyinosine + NH3 and Cyclic amidines + H2O <=> Cyclic amide + NH3. | 6 Protein of unknown function, without similarity to other proteins. | 0.505 |
| add | apt | PFREUD_04380 | PFREUD_11660 | Adenosine deaminase (Adenosine aminohydrolase); Adenosine + H2O <=> Inosine + NH3 and Deoxyadenosine + H2O <=> Deoxyinosine + NH3 and Cyclic amidines + H2O <=> Cyclic amide + NH3. | Adenine phosphoribosyltransferase (AMP:diphosphate phospho-D-ribosyltransferase); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.554 |
| add | guaA | PFREUD_04380 | PFREUD_06680 | Adenosine deaminase (Adenosine aminohydrolase); Adenosine + H2O <=> Inosine + NH3 and Deoxyadenosine + H2O <=> Deoxyinosine + NH3 and Cyclic amidines + H2O <=> Cyclic amide + NH3. | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | 0.661 |
| add | guaB1 | PFREUD_04380 | PFREUD_06480 | Adenosine deaminase (Adenosine aminohydrolase); Adenosine + H2O <=> Inosine + NH3 and Deoxyadenosine + H2O <=> Deoxyinosine + NH3 and Cyclic amidines + H2O <=> Cyclic amide + NH3. | Inosine-5-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD) / GMP reductase); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.455 |
| add | iunH | PFREUD_04380 | PFREUD_19310 | Adenosine deaminase (Adenosine aminohydrolase); Adenosine + H2O <=> Inosine + NH3 and Deoxyadenosine + H2O <=> Deoxyinosine + NH3 and Cyclic amidines + H2O <=> Cyclic amide + NH3. | Inosine/uridine-preferring nucleoside hydrolase (purine nucleosidase); Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. | 0.922 |
| add | polA | PFREUD_04380 | PFREUD_15360 | Adenosine deaminase (Adenosine aminohydrolase); Adenosine + H2O <=> Inosine + NH3 and Deoxyadenosine + H2O <=> Deoxyinosine + NH3 and Cyclic amidines + H2O <=> Cyclic amide + NH3. | Putative DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.429 |
| add | sbcC | PFREUD_04380 | PFREUD_04360 | Adenosine deaminase (Adenosine aminohydrolase); Adenosine + H2O <=> Inosine + NH3 and Deoxyadenosine + H2O <=> Deoxyinosine + NH3 and Cyclic amidines + H2O <=> Cyclic amide + NH3. | ATP-dependent dsDNA exonuclease SbcC; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3prime->5prime double strand exonuclease that can open hairpins. It also has a 5prim single-strand endonuclease activity. | 0.800 |
| add | sbcD | PFREUD_04380 | PFREUD_04370 | Adenosine deaminase (Adenosine aminohydrolase); Adenosine + H2O <=> Inosine + NH3 and Deoxyadenosine + H2O <=> Deoxyinosine + NH3 and Cyclic amidines + H2O <=> Cyclic amide + NH3. | SbcD, DNA repair exonuclease; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.806 |
| apt | add | PFREUD_11660 | PFREUD_04380 | Adenine phosphoribosyltransferase (AMP:diphosphate phospho-D-ribosyltransferase); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenosine deaminase (Adenosine aminohydrolase); Adenosine + H2O <=> Inosine + NH3 and Deoxyadenosine + H2O <=> Deoxyinosine + NH3 and Cyclic amidines + H2O <=> Cyclic amide + NH3. | 0.554 |
| apt | guaA | PFREUD_11660 | PFREUD_06680 | Adenine phosphoribosyltransferase (AMP:diphosphate phospho-D-ribosyltransferase); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | 0.991 |
| apt | guaB1 | PFREUD_11660 | PFREUD_06480 | Adenine phosphoribosyltransferase (AMP:diphosphate phospho-D-ribosyltransferase); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD) / GMP reductase); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.514 |
| apt | iunH | PFREUD_11660 | PFREUD_19310 | Adenine phosphoribosyltransferase (AMP:diphosphate phospho-D-ribosyltransferase); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine/uridine-preferring nucleoside hydrolase (purine nucleosidase); Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. | 0.937 |
| apt | polA | PFREUD_11660 | PFREUD_15360 | Adenine phosphoribosyltransferase (AMP:diphosphate phospho-D-ribosyltransferase); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.484 |
| guaA | add | PFREUD_06680 | PFREUD_04380 | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | Adenosine deaminase (Adenosine aminohydrolase); Adenosine + H2O <=> Inosine + NH3 and Deoxyadenosine + H2O <=> Deoxyinosine + NH3 and Cyclic amidines + H2O <=> Cyclic amide + NH3. | 0.661 |
| guaA | apt | PFREUD_06680 | PFREUD_11660 | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase (AMP:diphosphate phospho-D-ribosyltransferase); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.991 |
| guaA | guaB1 | PFREUD_06680 | PFREUD_06480 | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | Inosine-5-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD) / GMP reductase); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaA | polA | PFREUD_06680 | PFREUD_15360 | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | Putative DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.862 |