| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cbiE | cbiL | PFREUD_07700 | PFREUD_07680 | Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine. | CbiL Precorrin-2 C20-methyltransferase; Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | 0.999 |
| cbiE | cbiM | PFREUD_07700 | PFREUD_04590 | Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine. | Cobalt transport protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. | 0.966 |
| cbiE | cbiN | PFREUD_07700 | PFREUD_04580 | Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine. | CbiN is part of the active cobalt transport system involved in uptake of cobalt in to the cell involved with cobalamin biosynthesis (vitamin B12). | 0.964 |
| cbiE | cobA | PFREUD_07700 | PFREUD_04550 | Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine. | * 2 S-Adenosyl-L-methionine + Uroporphyrinogen III <=> 2 S-Adenosyl-L-homocysteine + Precorrin 2. | 0.949 |
| cbiE | cysG/cbiX | PFREUD_07700 | PFREUD_07710 | Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine. | CysG/CbiX; Cobalt fixation on precorrin 2. | 0.996 |
| cbiE | hemB | PFREUD_07700 | PFREUD_18910 | Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine. | Delta-aminolevulinic acid dehydratase (Porphobilinogen synthase); Porphyrin biosynthese. 2 5-aminolevulinate = porphobilinogen + 2 H2O cofactor : zinc; Belongs to the ALAD family. | 0.755 |
| cbiE | hemC | PFREUD_07700 | PFREUD_18960 | Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.864 |
| cbiE | hemD | PFREUD_07700 | PFREUD_20070 | Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine. | Uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.915 |
| cbiE | hemE | PFREUD_07700 | PFREUD_18950 | Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.888 |
| cbiE | nirA2/sir2 | PFREUD_07700 | PFREUD_21620 | Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine. | Sulfite reductase [ferredoxin]; Hydrogen sulfide + 6 oxidized ferredoxin + 3 H2O = sulfite + 6 reduced ferredoxin + 6 H+.Binds 1 siroheme per subunit Binds 1 4Fe-4S cluster per subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.831 |
| cbiL | cbiE | PFREUD_07680 | PFREUD_07700 | CbiL Precorrin-2 C20-methyltransferase; Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine. | 0.999 |
| cbiL | cbiM | PFREUD_07680 | PFREUD_04590 | CbiL Precorrin-2 C20-methyltransferase; Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | Cobalt transport protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. | 0.534 |
| cbiL | cbiN | PFREUD_07680 | PFREUD_04580 | CbiL Precorrin-2 C20-methyltransferase; Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | CbiN is part of the active cobalt transport system involved in uptake of cobalt in to the cell involved with cobalamin biosynthesis (vitamin B12). | 0.469 |
| cbiL | cobA | PFREUD_07680 | PFREUD_04550 | CbiL Precorrin-2 C20-methyltransferase; Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | * 2 S-Adenosyl-L-methionine + Uroporphyrinogen III <=> 2 S-Adenosyl-L-homocysteine + Precorrin 2. | 0.962 |
| cbiL | cysG/cbiX | PFREUD_07680 | PFREUD_07710 | CbiL Precorrin-2 C20-methyltransferase; Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | CysG/CbiX; Cobalt fixation on precorrin 2. | 0.979 |
| cbiL | hemB | PFREUD_07680 | PFREUD_18910 | CbiL Precorrin-2 C20-methyltransferase; Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | Delta-aminolevulinic acid dehydratase (Porphobilinogen synthase); Porphyrin biosynthese. 2 5-aminolevulinate = porphobilinogen + 2 H2O cofactor : zinc; Belongs to the ALAD family. | 0.541 |
| cbiL | hemD | PFREUD_07680 | PFREUD_20070 | CbiL Precorrin-2 C20-methyltransferase; Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | Uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.950 |
| cbiM | cbiE | PFREUD_04590 | PFREUD_07700 | Cobalt transport protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. | Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine. | 0.966 |
| cbiM | cbiL | PFREUD_04590 | PFREUD_07680 | Cobalt transport protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. | CbiL Precorrin-2 C20-methyltransferase; Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | 0.534 |
| cbiM | cbiN | PFREUD_04590 | PFREUD_04580 | Cobalt transport protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. | CbiN is part of the active cobalt transport system involved in uptake of cobalt in to the cell involved with cobalamin biosynthesis (vitamin B12). | 0.998 |