cbiN protein (Propionibacterium freudenreichii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

cbiN

CbiN is part of the active cobalt transport system involved in uptake of cobalt in to the cell involved with cobalamin biosynthesis (vitamin B12). (166 aa)

Predicted Functional Partners:

cbiM

0.998

cbiO1

0.996

cbiQ2

0.995

cbiE

0.964

cobA

0.836

cbiF

0.792

cysG/cbiX

0.774

dsbG

0.671

hemK

0.671

nrdJ

0.671

Your Current Organism:

Propionibacterium freudenreichii

NCBI taxonomy Id: 754252
Other names: P. freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii ATCC 9614, Propionibacterium freudenreichii subsp. shermanii CIP 103027, Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii str. CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii strain CIRM-BIA1

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cbiE	cbiF	PFREUD_07700	PFREUD_07690	Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine.	CbiF Precorrin-4 C11-methyltransferase; # S-Adenosyl-L-methionine + Precorrin 4 <=> S-Adenosyl-L-homocysteine + Precorrin 5.	0.999
cbiE	cbiM	PFREUD_07700	PFREUD_04590	Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine.	Cobalt transport protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.	0.966
cbiE	cbiN	PFREUD_07700	PFREUD_04580	Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine.	CbiN is part of the active cobalt transport system involved in uptake of cobalt in to the cell involved with cobalamin biosynthesis (vitamin B12).	0.964
cbiE	cbiO1	PFREUD_07700	PFREUD_04560	Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine.	Cobalt import ATP-binding protein CbiO; Part of an ABC transporter complex. Responsible for energy coupling to the transport system.	0.791
cbiE	cbiQ2	PFREUD_07700	PFREUD_04570	Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine.	Cobalt transport protein CbiQ.	0.848
cbiE	cobA	PFREUD_07700	PFREUD_04550	Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine.	* 2 S-Adenosyl-L-methionine + Uroporphyrinogen III <=> 2 S-Adenosyl-L-homocysteine + Precorrin 2.	0.949
cbiE	cysG/cbiX	PFREUD_07700	PFREUD_07710	Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine.	CysG/CbiX; Cobalt fixation on precorrin 2.	0.996
cbiE	nrdJ	PFREUD_07700	PFREUD_13010	Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine.	Vitamin B12-dependent ribonucleotide reductase (Ribonucleoside-diphosphate reductase NrdJ); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	0.637
cbiF	cbiE	PFREUD_07690	PFREUD_07700	CbiF Precorrin-4 C11-methyltransferase; # S-Adenosyl-L-methionine + Precorrin 4 <=> S-Adenosyl-L-homocysteine + Precorrin 5.	Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine.	0.999
cbiF	cbiM	PFREUD_07690	PFREUD_04590	CbiF Precorrin-4 C11-methyltransferase; # S-Adenosyl-L-methionine + Precorrin 4 <=> S-Adenosyl-L-homocysteine + Precorrin 5.	Cobalt transport protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.	0.660
cbiF	cbiN	PFREUD_07690	PFREUD_04580	CbiF Precorrin-4 C11-methyltransferase; # S-Adenosyl-L-methionine + Precorrin 4 <=> S-Adenosyl-L-homocysteine + Precorrin 5.	CbiN is part of the active cobalt transport system involved in uptake of cobalt in to the cell involved with cobalamin biosynthesis (vitamin B12).	0.792
cbiF	cobA	PFREUD_07690	PFREUD_04550	CbiF Precorrin-4 C11-methyltransferase; # S-Adenosyl-L-methionine + Precorrin 4 <=> S-Adenosyl-L-homocysteine + Precorrin 5.	* 2 S-Adenosyl-L-methionine + Uroporphyrinogen III <=> 2 S-Adenosyl-L-homocysteine + Precorrin 2.	0.442
cbiF	cysG/cbiX	PFREUD_07690	PFREUD_07710	CbiF Precorrin-4 C11-methyltransferase; # S-Adenosyl-L-methionine + Precorrin 4 <=> S-Adenosyl-L-homocysteine + Precorrin 5.	CysG/CbiX; Cobalt fixation on precorrin 2.	0.989
cbiF	dsbG	PFREUD_07690	PFREUD_08330	CbiF Precorrin-4 C11-methyltransferase; # S-Adenosyl-L-methionine + Precorrin 4 <=> S-Adenosyl-L-homocysteine + Precorrin 5.	DSBA oxidoreductase; Protein-disulfide isomerase.	0.659
cbiF	hemK	PFREUD_07690	PFREUD_10370	CbiF Precorrin-4 C11-methyltransferase; # S-Adenosyl-L-methionine + Precorrin 4 <=> S-Adenosyl-L-homocysteine + Precorrin 5.	Methylase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.	0.659
cbiF	nrdJ	PFREUD_07690	PFREUD_13010	CbiF Precorrin-4 C11-methyltransferase; # S-Adenosyl-L-methionine + Precorrin 4 <=> S-Adenosyl-L-homocysteine + Precorrin 5.	Vitamin B12-dependent ribonucleotide reductase (Ribonucleoside-diphosphate reductase NrdJ); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	0.664
cbiM	cbiE	PFREUD_04590	PFREUD_07700	Cobalt transport protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.	Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine.	0.966
cbiM	cbiF	PFREUD_04590	PFREUD_07690	Cobalt transport protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.	CbiF Precorrin-4 C11-methyltransferase; # S-Adenosyl-L-methionine + Precorrin 4 <=> S-Adenosyl-L-homocysteine + Precorrin 5.	0.660
cbiM	cbiN	PFREUD_04590	PFREUD_04580	Cobalt transport protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.	CbiN is part of the active cobalt transport system involved in uptake of cobalt in to the cell involved with cobalamin biosynthesis (vitamin B12).	0.998
cbiM	cbiO1	PFREUD_04590	PFREUD_04560	Cobalt transport protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.	Cobalt import ATP-binding protein CbiO; Part of an ABC transporter complex. Responsible for energy coupling to the transport system.	0.996

page 1 of 4

Server load: low (22%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About