STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cys1Cysteine synthase 1; Belongs to the cysteine synthase/cystathionine beta- synthase family. (308 aa)    
Predicted Functional Partners:
cysE
L-Serine + Acetyl-CoA <=> O-Acetyl-L-serine + CoA.
 
 0.996
metB
Cystathionine gamma-synthase (O-succinylhomoserine (thiol)-lyase).
  
 0.977
nirA2/sir2
Sulfite reductase [ferredoxin]; Hydrogen sulfide + 6 oxidized ferredoxin + 3 H2O = sulfite + 6 reduced ferredoxin + 6 H+.Binds 1 siroheme per subunit Binds 1 4Fe-4S cluster per subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
  
 
 0.954
serC
Phosphoserine aminotransferase (phosphoserine transaminase); Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.
  
 
 0.913
malY
Cysteine-S-conjugate beta-lyase; L-cystathionine + H2O = L-homocysteine + NH3 + pyruvate.
    
 0.913
cysK
Cysteine synthase (O-acetylserine sulfhydrylase); O3-acetyl-L-serine + H2S = L-cysteine + acetate. COFACTOR: Pyridoxal phosphate Belongs to the cysteine synthase/cystathionine beta-synthase family.
  
  
 
0.905
cys2
Cysteine synthase 2; Formation of cysteine from O-acetyl-serine and hydrogen sulfide. O3-acetyl-L-serine + H2S = L-cysteine + acetate; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
  
0.905
metH
Methionine synthase (5-methyltetrahydrofolate:L-homocysteine S-methyltransferase); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.871
sseB
Thiosulfate + Cyanide <=> Sulfite + Thiocyanate.
  
 
 0.859
luxS
S-ribosylhomocysteine lyase (Autoinducer-2 production protein luxS) (AI-2 synthesis protein); Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
  
 
 0.850
Your Current Organism:
Propionibacterium freudenreichii
NCBI taxonomy Id: 754252
Other names: P. freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii ATCC 9614, Propionibacterium freudenreichii subsp. shermanii CIP 103027, Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii str. CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii strain CIRM-BIA1
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