STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)    
Predicted Functional Partners:
fumC
Fumarate hydratase, class-II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.992
gltA1
Citrate synthase; Publication in : Nucleotide sequence, expression and transcriptional analysis of the Corynebacterium glutamicum gltA gene encoding citrate synthase. Microbiology 140:1817-1828(1994) - Acetyl-CoA + H2O + oxaloacetate = citrate + CoA. Weakly inhibited by ATP. Homohexamer. Citrate synthase is found in nearly all cells capable of oxidative metabolism.
  
 0.983
gltA2
Citrate + CoA <=> Acetyl-CoA + H2O + Oxaloacetate; Belongs to the citrate synthase family.
  
 0.976
PPA0888
NAD-dependent malic enzyme (NAD-ME) (Malate dehydrogenase); The protein has been identified by proteomics as a 70 kDa / PI 5.9 protein induced by various stresses including starvation.
  
 0.971
icd
Putative isocitrate/isopropylmalate dehydrogenase; Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
 
 0.944
CBL55744.1
Hypothetical secreted protein.
     
 0.929
nifJ1
Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin, which reduces nitrogenase, Pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin.
  
  
 0.909
nifJ2
Pyruvate:ferredoxin (Flavodoxin) oxidoreductase.
  
  
 0.884
gltB
Glutamate synthase large subunit (Ferredoxin); 2 L-Glutamate + 2 Oxidized ferredoxin <=> L-Glutamine + 2-Oxoglutarate + 2 Reduced ferredoxin.
  
 
 0.880
mutB
Methylmalonyl-CoA mutase catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. Induced by heat and acid stresses.
    
 0.875
Your Current Organism:
Propionibacterium freudenreichii
NCBI taxonomy Id: 754252
Other names: P. freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii ATCC 9614, Propionibacterium freudenreichii subsp. shermanii CIP 103027, Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii str. CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii strain CIRM-BIA1
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