| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBL56228.1 | CBL56263.1 | PFREUD_06970 | PFREUD_07320 | Silent information regulator protein Sir2 NAD-dependent deacetylase; Atalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. | Cell envelope-related transcriptional attenuator. | 0.667 |
| CBL56228.1 | CBL56621.1 | PFREUD_06970 | PFREUD_10980 | Silent information regulator protein Sir2 NAD-dependent deacetylase; Atalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. | AsnC-family transcriptional regulatory protein. | 0.555 |
| CBL56228.1 | CBL57523.1 | PFREUD_06970 | PFREUD_20300 | Silent information regulator protein Sir2 NAD-dependent deacetylase; Atalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. | Regulatory protein GntR, HTH. | 0.452 |
| CBL56228.1 | arsR4 | PFREUD_06970 | PFREUD_14990 | Silent information regulator protein Sir2 NAD-dependent deacetylase; Atalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. | Transcriptional regulator, ArsR family. | 0.552 |
| CBL56228.1 | cypA | PFREUD_06970 | PFREUD_23710 | Silent information regulator protein Sir2 NAD-dependent deacetylase; Atalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. | Cytochrome P450 (Heme-thiolate monooxygenase). | 0.513 |
| CBL56228.1 | dnaK2 | PFREUD_06970 | PFREUD_04630 | Silent information regulator protein Sir2 NAD-dependent deacetylase; Atalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. | Chaperone protein dnaK 2 (Heat shock protein 70 2) (Heat shock 70 kDa protein 2) (HSP70 2); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.448 |
| CBL56228.1 | gdh | PFREUD_06970 | PFREUD_17610 | Silent information regulator protein Sir2 NAD-dependent deacetylase; Atalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. | Glutamate dehydrogenase (NAD(P)-glutamate dehydrogenase); L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH. Homohexamer (By similarity). Belongs to the Glu/Leu/Phe/Val dehydrogenases family. Evidenced as a heat stress proetin in P. freudenreichii. | 0.578 |
| CBL56228.1 | metG | PFREUD_06970 | PFREUD_06960 | Silent information regulator protein Sir2 NAD-dependent deacetylase; Atalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. | Methionyl-tRNA synthetase (Methionine--tRNA ligase) (MetRS); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.489 |
| CBL56228.1 | sirR | PFREUD_06970 | PFREUD_20940 | Silent information regulator protein Sir2 NAD-dependent deacetylase; Atalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. | Iron dependent repressor. | 0.560 |
| CBL56228.1 | uvrD | PFREUD_06970 | PFREUD_09880 | Silent information regulator protein Sir2 NAD-dependent deacetylase; Atalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. | DNA helicase. | 0.585 |
| CBL56263.1 | CBL56228.1 | PFREUD_07320 | PFREUD_06970 | Cell envelope-related transcriptional attenuator. | Silent information regulator protein Sir2 NAD-dependent deacetylase; Atalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. | 0.667 |
| CBL56263.1 | CBL56621.1 | PFREUD_07320 | PFREUD_10980 | Cell envelope-related transcriptional attenuator. | AsnC-family transcriptional regulatory protein. | 0.657 |
| CBL56263.1 | CBL57523.1 | PFREUD_07320 | PFREUD_20300 | Cell envelope-related transcriptional attenuator. | Regulatory protein GntR, HTH. | 0.427 |
| CBL56263.1 | arsR4 | PFREUD_07320 | PFREUD_14990 | Cell envelope-related transcriptional attenuator. | Transcriptional regulator, ArsR family. | 0.734 |
| CBL56263.1 | sirR | PFREUD_07320 | PFREUD_20940 | Cell envelope-related transcriptional attenuator. | Iron dependent repressor. | 0.550 |
| CBL56621.1 | CBL56228.1 | PFREUD_10980 | PFREUD_06970 | AsnC-family transcriptional regulatory protein. | Silent information regulator protein Sir2 NAD-dependent deacetylase; Atalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. | 0.555 |
| CBL56621.1 | CBL56263.1 | PFREUD_10980 | PFREUD_07320 | AsnC-family transcriptional regulatory protein. | Cell envelope-related transcriptional attenuator. | 0.657 |
| CBL57523.1 | CBL56228.1 | PFREUD_20300 | PFREUD_06970 | Regulatory protein GntR, HTH. | Silent information regulator protein Sir2 NAD-dependent deacetylase; Atalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. | 0.452 |
| CBL57523.1 | CBL56263.1 | PFREUD_20300 | PFREUD_07320 | Regulatory protein GntR, HTH. | Cell envelope-related transcriptional attenuator. | 0.427 |
| CBL57523.1 | sirR | PFREUD_20300 | PFREUD_20940 | Regulatory protein GntR, HTH. | Iron dependent repressor. | 0.589 |