| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBL56181.1 | aroF | PFREUD_06500 | PFREUD_11530 | Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine. | Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.973 |
| CBL56181.1 | dhbC | PFREUD_06500 | PFREUD_05130 | Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine. | Menaquinone-specific isochorismate synthase; Chorismate <=> Isochorismate. | 0.856 |
| CBL56181.1 | hisC | PFREUD_06500 | PFREUD_11780 | Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine. | Histidinol-phosphate aminotransferase (Imidazole acetol-phosphate transaminase); L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.427 |
| CBL56181.1 | menF | PFREUD_06500 | PFREUD_07520 | Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine. | Isochorismate synthetase (enterochelin biosynthesis); Chorismate <=> Isochorismate. | 0.856 |
| CBL56181.1 | trpE | PFREUD_06500 | PFREUD_11910 | Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.916 |
| CBL56181.1 | tyrB | PFREUD_06500 | PFREUD_09460 | Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine. | Aspartate transaminase (Aminotransferase); L-Aspartate + 2-Oxoglutarate <=> Oxaloacetate + L-Glutamate. | 0.929 |
| aroF | CBL56181.1 | PFREUD_11530 | PFREUD_06500 | Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine. | 0.973 |
| aroF | dhbC | PFREUD_11530 | PFREUD_05130 | Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Menaquinone-specific isochorismate synthase; Chorismate <=> Isochorismate. | 0.846 |
| aroF | hisC | PFREUD_11530 | PFREUD_11780 | Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Histidinol-phosphate aminotransferase (Imidazole acetol-phosphate transaminase); L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.737 |
| aroF | menF | PFREUD_11530 | PFREUD_07520 | Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Isochorismate synthetase (enterochelin biosynthesis); Chorismate <=> Isochorismate. | 0.888 |
| aroF | trpC | PFREUD_11530 | PFREUD_11900 | Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Indole-3-glycerol phosphate synthase (TrpC); 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O; Belongs to the TrpC family. | 0.751 |
| aroF | trpE | PFREUD_11530 | PFREUD_11910 | Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.963 |
| dhbC | CBL56181.1 | PFREUD_05130 | PFREUD_06500 | Menaquinone-specific isochorismate synthase; Chorismate <=> Isochorismate. | Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine. | 0.856 |
| dhbC | aroF | PFREUD_05130 | PFREUD_11530 | Menaquinone-specific isochorismate synthase; Chorismate <=> Isochorismate. | Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.846 |
| dhbC | hisC | PFREUD_05130 | PFREUD_11780 | Menaquinone-specific isochorismate synthase; Chorismate <=> Isochorismate. | Histidinol-phosphate aminotransferase (Imidazole acetol-phosphate transaminase); L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.800 |
| dhbC | menB | PFREUD_05130 | PFREUD_07540 | Menaquinone-specific isochorismate synthase; Chorismate <=> Isochorismate. | Naphthoate synthase (Dihydroxynaphthoic acid synthetase); Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. | 0.825 |
| dhbC | menD | PFREUD_05130 | PFREUD_07490 | Menaquinone-specific isochorismate synthase; Chorismate <=> Isochorismate. | Menaquinone biosynthesis protein; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. | 0.986 |
| dhbC | menE2 | PFREUD_05130 | PFREUD_07530 | Menaquinone-specific isochorismate synthase; Chorismate <=> Isochorismate. | O-succinylbenzoic acid-CoA ligase (2-succinylbenzoate--CoA ligase); ATP + 2-Succinylbenzoate + CoA <=> AMP + Pyrophosphate + 2-Succinylbenzoyl-CoA - Cofactor biosynthesis; menaquinone biosynthesis; menaquinone from chorismate: step 4/7. | 0.644 |
| dhbC | menF | PFREUD_05130 | PFREUD_07520 | Menaquinone-specific isochorismate synthase; Chorismate <=> Isochorismate. | Isochorismate synthetase (enterochelin biosynthesis); Chorismate <=> Isochorismate. | 0.927 |
| dhbC | trpC | PFREUD_05130 | PFREUD_11900 | Menaquinone-specific isochorismate synthase; Chorismate <=> Isochorismate. | Indole-3-glycerol phosphate synthase (TrpC); 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O; Belongs to the TrpC family. | 0.406 |
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