STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mutAMethylmalonyl-CoA mutase small subunit (Methylmalonyl-CoA mutase beta subunit) (MCB-beta); Methylmalonyl-CoA mutase catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. Induced by heat and acid stresses. (638 aa)    
Predicted Functional Partners:
mutB
Methylmalonyl-CoA mutase catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. Induced by heat and acid stresses.
 
0.999
CBL56582.1
Methylmalonyl-CoA epimerase; (R)-2-Methyl-3-oxopropanoyl-CoA <=> (S)-2-Methyl-3-oxopropanoyl-CoA.
 
  
 0.977
argK
Kinase ArgK.
 
  
 0.972
nifJ2
Pyruvate:ferredoxin (Flavodoxin) oxidoreductase.
    
 0.881
nifJ1
Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin, which reduces nitrogenase, Pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin.
    
 0.880
gltA1
Citrate synthase; Publication in : Nucleotide sequence, expression and transcriptional analysis of the Corynebacterium glutamicum gltA gene encoding citrate synthase. Microbiology 140:1817-1828(1994) - Acetyl-CoA + H2O + oxaloacetate = citrate + CoA. Weakly inhibited by ATP. Homohexamer. Citrate synthase is found in nearly all cells capable of oxidative metabolism.
     
 0.867
CBL56066.1
Pyruvate flavodoxin/ferredoxin oxidoreductase.
     
 0.846
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
     
 0.838
cat
Coenzyme A transferase (Putative succinyl-CoA or butyryl-CoA:coenzyme A transferase); acyl-CoA + acetate = a fatty acid anion + acetyl-CoA OR: succinate + acetyl-CoA = succinyl-CoA + acetate OR (in Pf): succinate + propionyl-CoA = succinyl-CoA + propionate.
    
 0.828
bkdB
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Similarity to Swiss-Prot entry Q9IMO.
   
 
 0.813
Your Current Organism:
Propionibacterium freudenreichii
NCBI taxonomy Id: 754252
Other names: P. freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii ATCC 9614, Propionibacterium freudenreichii subsp. shermanii CIP 103027, Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii str. CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii strain CIRM-BIA1
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.