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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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lpdBIn the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12, and catalyses oxidation of its dihydrolipoyl groups. It plays a similar role in the oxoglutarate and 3-methyl-2-oxobutanoate dehydrogenase complexes Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH. (476 aa)    
Predicted Functional Partners:
odhA
2-oxoglutarate dehydrogenase, E1 and E2 components; Annotated from high similarity with Swiss-Prot entry Q8NRC3, a bifunctional enzyme of Corynebacterium glutamicum with E1 and E2 activity. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
  
 0.994
bkdA2
2-oxoisovalerate dehydrogenase subunit beta Pyruvate dehydrogenase E1 component subunit beta; 44% identity with Swiss-Prot entry P09061.
 
 0.928
pdhB
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Succinyl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [Dihydrolipoyllysine-residue succinyltransferase]S-succinyldihydrolipoyllysine, Glutaryl-CoA + Dihydrolipoamide <=> CoA + S-Glutaryldihydrolipoamide.
 0.904
bkdB
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Similarity to Swiss-Prot entry Q9IMO.
 
 0.903
bkdA1
Pyruvate dehydrogenase E1 component alpha subunit; Similar to Swiss-Prot entries Q9I1M2 and P09060.
 
 
 0.809
aceE
Dehydrogenase E1 component (2-oxo-acid dehydrogenase E1 subunit, homodimeric type); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.792
gcvT1
Glycine cleavage system T protein, aminomethyltransferase; S-Aminomethyldihydrolipoylprotein + Tetrahydrofolate <=> Dihydrolipoylprotein + 5,10-Methylenetetrahydrofolate + NH3.
 
 0.757
gcvP
Glycine dehydrogenase [decarboxylating] (Glycine decarboxylase) (Glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
 0.755
trxA2
Thioredoxin.
   
 0.636
gcvH
Glycine cleavage H-protein (lipoate-binding); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 
 0.575
Your Current Organism:
Propionibacterium freudenreichii
NCBI taxonomy Id: 754252
Other names: P. freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii ATCC 9614, Propionibacterium freudenreichii subsp. shermanii CIP 103027, Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii str. CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii strain CIRM-BIA1
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