| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBL56181.1 | aroA | PFREUD_06500 | PFREUD_10180 | Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.810 |
| CBL56181.1 | aroB | PFREUD_06500 | PFREUD_11520 | Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine. | 3-dehydroquinate synthase / shikimate kinase, bifunctionnal enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.854 |
| CBL56181.1 | aroE | PFREUD_06500 | PFREUD_01580 | Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine. | Shikimate + NADP+ <=> 3-Dehydroshikimate + NADPH + H+ and Shikimate + NADP+ <=> 5-Dehydroshikimate + NADPH. | 0.429 |
| CBL56181.1 | aroF | PFREUD_06500 | PFREUD_11530 | Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine. | Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.973 |
| CBL56181.1 | serC | PFREUD_06500 | PFREUD_18160 | Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine. | Phosphoserine aminotransferase (phosphoserine transaminase); Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. | 0.532 |
| CBL56181.1 | tyrA | PFREUD_06500 | PFREUD_11280 | Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine. | Prephenate + NAD+ <=> 3-(4-Hydroxyphenyl)pyruvate + CO2 + NADH + H+. | 0.953 |
| CBL56540.1 | CBL56543.1 | PFREUD_10160 | PFREUD_10190 | Monophosphatase. | 5.2 Protein of unknown function similar to proteins from other organisms; Belongs to the SOS response-associated peptidase family. | 0.541 |
| CBL56540.1 | aroA | PFREUD_10160 | PFREUD_10180 | Monophosphatase. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.729 |
| CBL56540.1 | engC | PFREUD_10160 | PFREUD_10170 | Monophosphatase. | GTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. | 0.732 |
| CBL56543.1 | CBL56540.1 | PFREUD_10190 | PFREUD_10160 | 5.2 Protein of unknown function similar to proteins from other organisms; Belongs to the SOS response-associated peptidase family. | Monophosphatase. | 0.541 |
| CBL56543.1 | aroA | PFREUD_10190 | PFREUD_10180 | 5.2 Protein of unknown function similar to proteins from other organisms; Belongs to the SOS response-associated peptidase family. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.725 |
| CBL56543.1 | engC | PFREUD_10190 | PFREUD_10170 | 5.2 Protein of unknown function similar to proteins from other organisms; Belongs to the SOS response-associated peptidase family. | GTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. | 0.726 |
| aroA | CBL56181.1 | PFREUD_10180 | PFREUD_06500 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine. | 0.810 |
| aroA | CBL56540.1 | PFREUD_10180 | PFREUD_10160 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Monophosphatase. | 0.729 |
| aroA | CBL56543.1 | PFREUD_10180 | PFREUD_10190 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 5.2 Protein of unknown function similar to proteins from other organisms; Belongs to the SOS response-associated peptidase family. | 0.725 |
| aroA | aroB | PFREUD_10180 | PFREUD_11520 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 3-dehydroquinate synthase / shikimate kinase, bifunctionnal enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.999 |
| aroA | aroE | PFREUD_10180 | PFREUD_01580 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Shikimate + NADP+ <=> 3-Dehydroshikimate + NADPH + H+ and Shikimate + NADP+ <=> 5-Dehydroshikimate + NADPH. | 0.955 |
| aroA | aroF | PFREUD_10180 | PFREUD_11530 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.993 |
| aroA | cmk | PFREUD_10180 | PFREUD_11270 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Cytidylate kinase (CK) (Cytidine monophosphate kinase) (CMP kinase); Cytidylate kinase EC:2.7.4.14 catalyses the phosphorylation of cytidine 5prime-monophosphate (dCMP) to cytidine 5prime-diphosphate (dCDP) in the presence of ATP or GTP. | 0.833 |
| aroA | engC | PFREUD_10180 | PFREUD_10170 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | GTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. | 0.909 |