| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| atpA | atpB | PFREUD_10470 | PFREUD_10430 | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | 0.999 |
| atpA | atpC | PFREUD_10470 | PFREUD_10500 | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | ATP synthase epsilon chain (ATP synthase F1 sector epsilon subunit); Produces ATP from ADP in the presence of a proton gradient across the membrane. | 0.999 |
| atpA | atpD | PFREUD_10470 | PFREUD_10490 | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | ATP synthase subunit beta (ATPase subunit beta) (ATP synthase F1 sector subunit beta); Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. | 0.999 |
| atpA | atpE | PFREUD_10470 | PFREUD_10440 | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | ATP synthase C chain (F1F0-ATPase subunit c); F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | 0.999 |
| atpA | atpF | PFREUD_10470 | PFREUD_10450 | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | ATP synthase B chain (F0F1 ATP synthase subunit B); Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. | 0.999 |
| atpA | atpG | PFREUD_10470 | PFREUD_10480 | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | ATP synthase gamma chain (ATP synthase F1 sector gamma subunit); Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. | 0.999 |
| atpA | atpH | PFREUD_10470 | PFREUD_10460 | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | ATP synthase delta chain; This protein seems to be part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) into CF(1) or is implicated in proton conduction [H]. ATP + H2O + H+(In) = ADP + phosphate + H+(Out). | 0.999 |
| atpA | rpsL | PFREUD_10470 | PFREUD_05620 | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | 30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. | 0.751 |
| atpA | tsf | PFREUD_10470 | PFREUD_14770 | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | Elongation factor Ts (EF-Ts); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. | 0.782 |
| atpB | atpA | PFREUD_10430 | PFREUD_10470 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | 0.999 |
| atpB | atpC | PFREUD_10430 | PFREUD_10500 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | ATP synthase epsilon chain (ATP synthase F1 sector epsilon subunit); Produces ATP from ADP in the presence of a proton gradient across the membrane. | 0.999 |
| atpB | atpD | PFREUD_10430 | PFREUD_10490 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | ATP synthase subunit beta (ATPase subunit beta) (ATP synthase F1 sector subunit beta); Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. | 0.999 |
| atpB | atpE | PFREUD_10430 | PFREUD_10440 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | ATP synthase C chain (F1F0-ATPase subunit c); F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | 0.999 |
| atpB | atpF | PFREUD_10430 | PFREUD_10450 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | ATP synthase B chain (F0F1 ATP synthase subunit B); Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. | 0.999 |
| atpB | atpG | PFREUD_10430 | PFREUD_10480 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | ATP synthase gamma chain (ATP synthase F1 sector gamma subunit); Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. | 0.999 |
| atpB | atpH | PFREUD_10430 | PFREUD_10460 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | ATP synthase delta chain; This protein seems to be part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) into CF(1) or is implicated in proton conduction [H]. ATP + H2O + H+(In) = ADP + phosphate + H+(Out). | 0.999 |
| atpB | rplM | PFREUD_10430 | PFREUD_06240 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | 50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.615 |
| atpB | rpsL | PFREUD_10430 | PFREUD_05620 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | 30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. | 0.762 |
| atpB | tsf | PFREUD_10430 | PFREUD_14770 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | Elongation factor Ts (EF-Ts); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. | 0.779 |
| atpC | atpA | PFREUD_10500 | PFREUD_10470 | ATP synthase epsilon chain (ATP synthase F1 sector epsilon subunit); Produces ATP from ADP in the presence of a proton gradient across the membrane. | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | 0.999 |