| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| atpA | atpB | PFREUD_10470 | PFREUD_10430 | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | 0.999 |
| atpA | atpC | PFREUD_10470 | PFREUD_10500 | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | ATP synthase epsilon chain (ATP synthase F1 sector epsilon subunit); Produces ATP from ADP in the presence of a proton gradient across the membrane. | 0.999 |
| atpA | atpD | PFREUD_10470 | PFREUD_10490 | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | ATP synthase subunit beta (ATPase subunit beta) (ATP synthase F1 sector subunit beta); Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. | 0.999 |
| atpA | atpE | PFREUD_10470 | PFREUD_10440 | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | ATP synthase C chain (F1F0-ATPase subunit c); F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | 0.999 |
| atpA | atpF | PFREUD_10470 | PFREUD_10450 | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | ATP synthase B chain (F0F1 ATP synthase subunit B); Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. | 0.999 |
| atpA | atpG | PFREUD_10470 | PFREUD_10480 | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | ATP synthase gamma chain (ATP synthase F1 sector gamma subunit); Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. | 0.999 |
| atpA | atpH | PFREUD_10470 | PFREUD_10460 | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | ATP synthase delta chain; This protein seems to be part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) into CF(1) or is implicated in proton conduction [H]. ATP + H2O + H+(In) = ADP + phosphate + H+(Out). | 0.999 |
| atpA | nuoD | PFREUD_10470 | PFREUD_05190 | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | NADH-quinone oxidoreductase chain D (EC 1.6.99.5) (NADH dehydrogenase I, chain D); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 49 kDa subunit family. | 0.920 |
| atpA | odhA | PFREUD_10470 | PFREUD_10250 | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | 2-oxoglutarate dehydrogenase, E1 and E2 components; Annotated from high similarity with Swiss-Prot entry Q8NRC3, a bifunctional enzyme of Corynebacterium glutamicum with E1 and E2 activity. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). | 0.981 |
| atpA | rpoB | PFREUD_10470 | PFREUD_05600 | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.921 |
| atpB | atpA | PFREUD_10430 | PFREUD_10470 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | ATP synthase subunit alpha (ATPase subunit alpha) (ATP synthase F1 sector subunit alpha); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | 0.999 |
| atpB | atpC | PFREUD_10430 | PFREUD_10500 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | ATP synthase epsilon chain (ATP synthase F1 sector epsilon subunit); Produces ATP from ADP in the presence of a proton gradient across the membrane. | 0.999 |
| atpB | atpD | PFREUD_10430 | PFREUD_10490 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | ATP synthase subunit beta (ATPase subunit beta) (ATP synthase F1 sector subunit beta); Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. | 0.999 |
| atpB | atpE | PFREUD_10430 | PFREUD_10440 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | ATP synthase C chain (F1F0-ATPase subunit c); F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | 0.999 |
| atpB | atpF | PFREUD_10430 | PFREUD_10450 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | ATP synthase B chain (F0F1 ATP synthase subunit B); Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. | 0.999 |
| atpB | atpG | PFREUD_10430 | PFREUD_10480 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | ATP synthase gamma chain (ATP synthase F1 sector gamma subunit); Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. | 0.999 |
| atpB | atpH | PFREUD_10430 | PFREUD_10460 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | ATP synthase delta chain; This protein seems to be part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) into CF(1) or is implicated in proton conduction [H]. ATP + H2O + H+(In) = ADP + phosphate + H+(Out). | 0.999 |
| atpB | nuoD | PFREUD_10430 | PFREUD_05190 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | NADH-quinone oxidoreductase chain D (EC 1.6.99.5) (NADH dehydrogenase I, chain D); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 49 kDa subunit family. | 0.410 |
| atpB | odhA | PFREUD_10430 | PFREUD_10250 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | 2-oxoglutarate dehydrogenase, E1 and E2 components; Annotated from high similarity with Swiss-Prot entry Q8NRC3, a bifunctional enzyme of Corynebacterium glutamicum with E1 and E2 activity. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). | 0.410 |
| atpB | rpoB | PFREUD_10430 | PFREUD_05600 | ATP synthase A chain (ATPase protein 6) (F1F0-ATPase subunit a); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.483 |
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