STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ldh1L-Lactate dehydrogenase; (S)-Lactate + NAD+ <=> Pyruvate + NADH + H+; Belongs to the LDH/MDH superfamily. (326 aa)    
Predicted Functional Partners:
nifJ1
Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin, which reduces nitrogenase, Pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin.
  
 
 0.991
nifJ2
Pyruvate:ferredoxin (Flavodoxin) oxidoreductase.
  
 
 0.987
pyk1
Pyruvate kinase 1; ATP + Pyruvate <=> ADP + Phosphoenolpyruvate; Belongs to the pyruvate kinase family.
  
 0.970
CBL56066.1
Pyruvate flavodoxin/ferredoxin oxidoreductase.
  
 
 0.956
aceE
Dehydrogenase E1 component (2-oxo-acid dehydrogenase E1 subunit, homodimeric type); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
     
 0.947
ldh2
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate.
  
  
0.941
dld
D-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family.
   
 
 0.939
ppdk
6 Protein of unknown function, without similarity to other proteins; Belongs to the PEP-utilizing enzyme family.
  
 
 0.936
bkdA2
2-oxoisovalerate dehydrogenase subunit beta Pyruvate dehydrogenase E1 component subunit beta; 44% identity with Swiss-Prot entry P09061.
   
 0.928
PPA0888
NAD-dependent malic enzyme (NAD-ME) (Malate dehydrogenase); The protein has been identified by proteomics as a 70 kDa / PI 5.9 protein induced by various stresses including starvation.
  
 0.927
Your Current Organism:
Propionibacterium freudenreichii
NCBI taxonomy Id: 754252
Other names: P. freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii ATCC 9614, Propionibacterium freudenreichii subsp. shermanii CIP 103027, Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii str. CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii strain CIRM-BIA1
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