| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBL56265.1 | gpm1 | PFREUD_07340 | PFREUD_24080 | Hypothetical membrane protein. | Phosphoglycerate mutase/fructose-2,6-bisphosphatase. | 0.557 |
| CBL56265.1 | pf774 | PFREUD_07340 | PFREUD_04240 | Hypothetical membrane protein. | Putative carboxylic ester hydrolase. | 0.758 |
| CBL56265.1 | pgm | PFREUD_07340 | PFREUD_12180 | Hypothetical membrane protein. | Phosphoglycerate mutase; 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate and 3-Phospho-D-glyceroyl phosphate <=> 2,3-Bisphospho-D-glycerate. | 0.635 |
| cbiA | cbiB/cobD | PFREUD_12220 | PFREUD_12190 | Cobyrinic acid A,C-diamide synthase, CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | CbiB/CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.982 |
| cbiA | cbiE | PFREUD_12220 | PFREUD_07700 | Cobyrinic acid A,C-diamide synthase, CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine. | 0.997 |
| cbiA | cbiP/cobQ | PFREUD_12220 | PFREUD_12200 | Cobyrinic acid A,C-diamide synthase, CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobyric acid synthase CbiP/CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.996 |
| cbiA | cobA2 | PFREUD_12220 | PFREUD_12210 | Cobyrinic acid A,C-diamide synthase, CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cob(I)alamin adenosyltransferase; Cob(I)yrinate a,c diamide + ATP <=> Adenosyl cobyrinate a,c diamide + Triphosphate. | 0.997 |
| cbiA | cobS | PFREUD_12220 | PFREUD_12240 | Cobyrinic acid A,C-diamide synthase, CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobalamin 5-phosphate synthase (adenosylcobinamide-GDP ribazoletransferase); Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.978 |
| cbiA | cobU | PFREUD_12220 | PFREUD_12230 | Cobyrinic acid A,C-diamide synthase, CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | CobU Bifunctional cobalamin biosynthesis pyrophosphate enzyme; Adenosyl cobinamide phosphate + GTP <=> Adenosine-GDP-cobinamide + Pyrophosphate. | 0.994 |
| cbiA | gpm1 | PFREUD_12220 | PFREUD_24080 | Cobyrinic acid A,C-diamide synthase, CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Phosphoglycerate mutase/fructose-2,6-bisphosphatase. | 0.440 |
| cbiA | pgm | PFREUD_12220 | PFREUD_12180 | Cobyrinic acid A,C-diamide synthase, CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Phosphoglycerate mutase; 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate and 3-Phospho-D-glyceroyl phosphate <=> 2,3-Bisphospho-D-glycerate. | 0.713 |
| cbiB/cobD | cbiA | PFREUD_12190 | PFREUD_12220 | CbiB/CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Cobyrinic acid A,C-diamide synthase, CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.982 |
| cbiB/cobD | cbiE | PFREUD_12190 | PFREUD_07700 | CbiB/CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine. | 0.962 |
| cbiB/cobD | cbiP/cobQ | PFREUD_12190 | PFREUD_12200 | CbiB/CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Cobyric acid synthase CbiP/CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.999 |
| cbiB/cobD | cobA2 | PFREUD_12190 | PFREUD_12210 | CbiB/CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Cob(I)alamin adenosyltransferase; Cob(I)yrinate a,c diamide + ATP <=> Adenosyl cobyrinate a,c diamide + Triphosphate. | 0.996 |
| cbiB/cobD | cobS | PFREUD_12190 | PFREUD_12240 | CbiB/CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Cobalamin 5-phosphate synthase (adenosylcobinamide-GDP ribazoletransferase); Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.973 |
| cbiB/cobD | cobU | PFREUD_12190 | PFREUD_12230 | CbiB/CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | CobU Bifunctional cobalamin biosynthesis pyrophosphate enzyme; Adenosyl cobinamide phosphate + GTP <=> Adenosine-GDP-cobinamide + Pyrophosphate. | 0.998 |
| cbiB/cobD | pgm | PFREUD_12190 | PFREUD_12180 | CbiB/CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Phosphoglycerate mutase; 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate and 3-Phospho-D-glyceroyl phosphate <=> 2,3-Bisphospho-D-glycerate. | 0.623 |
| cbiE | cbiA | PFREUD_07700 | PFREUD_12220 | Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine. | Cobyrinic acid A,C-diamide synthase, CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.997 |
| cbiE | cbiB/cobD | PFREUD_07700 | PFREUD_12190 | Precorrin methylase (precorrin-3B C17-methyltransferase) CbiE/G/H fusion protein; S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 / Cobalt-precorrin 3 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 4 + S-Adenosyl-L-homocysteine. | CbiB/CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.962 |